{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T13:56:26Z","timestamp":1761918986396,"version":"3.40.4"},"reference-count":10,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Most cases of constitutional 11q terminal deletion disorder are children. Malignancy is a potential concern, as these children reach adulthood. However, since the majority of patients are young, their risk of developing malignancy in adulthood is essentially unknown. &lt;i&gt;Aim:&lt;\/i&gt; To report the first hematologic malignancy [extranodal natural killer (NK)\/T-cell lymphoma, nasal type] arising in the trachea of a patient with constitutional 11q terminal deletion disorder. Our patient is the oldest patient reported in the literature. It is of note that this cytogenetic abnormality has not been described as a recurring abnormality in extranodal NK\/T-cell lymphoma. &lt;i&gt;Case Report:&lt;\/i&gt; A 36-year-old male with congenital psychomotor retardation was transferred to our hospital. Pathologic evaluation was diagnostic of extranodal NK\/T-cell lymphoma, nasal type. Staging marrow was negative for lymphoma, but cytogenetic analysis revealed a constitutional deletion of chromosome 11 at band q23 [46,XY,del(11)(q23)(c)]. This abnormality was present in a subsequent bone marrow specimen, along with an acquired abnormality, namely an extra copy of part of the long arm of chromosome 1 translocated to the short arm of chromosome 14. &lt;i&gt;Conclusion:&lt;\/i&gt; Patients with 11q terminal deletion disorder who reach adulthood may be predisposed to develop neoplasias by virtue of the constitutional deletion.<\/jats:p>","DOI":"10.1159\/000101998","type":"journal-article","created":{"date-parts":[[2007,4,27]],"date-time":"2007-04-27T10:30:09Z","timestamp":1177669809000},"page":"42-46","source":"Crossref","is-referenced-by-count":2,"title":["Extranodal Natural Killer\/T-Cell Lymphoma, Nasal Type, in a Patient with a Constitutional 11q Terminal Deletion Disorder"],"prefix":"10.1159","volume":"118","author":[{"given":"Sujata","family":"Gaitonde","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anoja","family":"Attele","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syed A.","family":"Abutalib","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Damiano","family":"Rondelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valerie","family":"Lindgren","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2007,4,27]]},"reference":[{"doi-asserted-by":"publisher","key":"ref1","DOI":"10.3109%2F08880019209018329"},{"doi-asserted-by":"publisher","key":"ref2","DOI":"10.1002%2F%28SICI%291098-2264%28199610%2917%3A2%3C94%3A%3AAID-GCC4%3E3.0.CO%3B2-W"},{"doi-asserted-by":"publisher","key":"ref3","DOI":"10.1002%2Fajmg.a.30090"},{"doi-asserted-by":"publisher","key":"ref4","DOI":"10.1002%2F%28SICI%291098-2264%28199910%2926%3A2%3C176%3A%3AAID-GCC11%3E3.0.CO%3B2-3"},{"doi-asserted-by":"publisher","key":"ref5","DOI":"10.1038%2Fng1183"},{"doi-asserted-by":"publisher","key":"ref6","DOI":"10.1086%2F302999"},{"doi-asserted-by":"publisher","key":"ref7","DOI":"10.1038%2Fsj.onc.1202887"},{"doi-asserted-by":"publisher","key":"ref8","DOI":"10.1046%2Fj.1365-2141.1997.752711.x"},{"doi-asserted-by":"publisher","key":"ref9","DOI":"10.1002%2F%28SICI%291096-8628%2819960315%2962%3A2%3C120%3A%3AAID-AJMG4%3E3.0.CO%3B2-%23"},{"doi-asserted-by":"publisher","key":"ref10","DOI":"10.1159%2F000152624"}],"container-title":["Acta Haematologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/101998","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/101998","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:29:18Z","timestamp":1745461758000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000101998"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":10,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2007,6,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000101998","archive":["Portico"],"relation":{},"ISSN":["0001-5792","1421-9662"],"issn-type":[{"type":"print","value":"0001-5792"},{"type":"electronic","value":"1421-9662"}],"subject":[],"published":{"date-parts":[[2007]]}}}