{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,20]],"date-time":"2026-01-20T10:17:29Z","timestamp":1768904249561,"version":"3.49.0"},"reference-count":16,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>&lt;i&gt;Introduction:&lt;\/i&gt; Hidradenitis suppurativa is a chronic inflammatory disease characterized by significant morbidity. Current medical therapies are usually only minimally effective. &lt;i&gt;Objective:&lt;\/i&gt; To assess the efficacy and safety of infliximab monotherapy for the treatment of severe extensive refractory forms of hidradenitis suppurativa. &lt;i&gt;Design:&lt;\/i&gt; A retrospective study in a group of 6 patients who received treatment with infliximab for hidradenitis suppurativa, in the Dermatology Department of the University Hospital of Puerto Real in the last year. The dose was 5\u201310 mg\/kg at weeks 0, 2 and 6, followed by a maintenance dose every 4 weeks. Subjective and objective efficacy was assessed before and after each treatment session. &lt;i&gt;Results:&lt;\/i&gt; All patients experienced improvement in subjective symptoms after the initial dose. A decrease in exudation, the size and number of lesions and less development of fistulous tracts were observed. The patients were followed up during 6 months. Treatment was generally well tolerated and there was only one mild reaction to the infusion in the form of headache. No patient required treatment discontinuation due to adverse effects. &lt;i&gt;Conclusions:&lt;\/i&gt; Infliximab was shown to be an effective therapeutic alternative for severe extensive forms of hidradenitis suppurativa when it is used as monotherapy.<\/jats:p>","DOI":"10.1159\/000102032","type":"journal-article","created":{"date-parts":[[2007,6,22]],"date-time":"2007-06-22T11:07:15Z","timestamp":1182510435000},"page":"41-44","source":"Crossref","is-referenced-by-count":37,"title":["Infliximab for the Treatment of Hidradenitis Suppurativa"],"prefix":"10.1159","volume":"215","author":[{"given":"J.M.","family":"Fern\u00e1ndez-Vozmediano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.C.","family":"Armario-Hita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2007,6,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002%2F1529-0131%28199809%2941%3A9%3C1552%3A%3AAID-ART5%3E3.0.CO%3B2-W"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002%2Fart.20967"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2805%2967566-6"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002%2Fbjs.1800840331"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2894%2990628-9"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1097%2F00054725-200111000-00008"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1572-0241.2002.05950.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0190-9622%2803%2901132-0"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.139.12.1540"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.2003.05663.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.142.9.1110"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159%2F000096194"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159%2F000087013"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.2006.07528.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159%2F000095033"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1159%2F000081494"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/102032","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/102032","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:29:33Z","timestamp":1745461773000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000102032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":16,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2007,6,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000102032","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007]]}}}