{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T02:20:23Z","timestamp":1792376423032,"version":"4.4.0"},"reference-count":13,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Neurol"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>It has been reported that the tumor necrosis factor (TNF)\u03b1 promoter polymorphism is associated with autoimmune disease and inflammatory disease. It has also been claimed that this polymorphism may affect TNF\u03b1 expression. We investigated the TNF\u03b1 \u2013308 polymorphism and TNF\u03b1 levels in 79 unrelated Chinese patients with Guillain-Barr\u00e9 syndrome (GBS) and 78 healthy controls using PCR-RFLP and ELISA assay. Patients with GBS were divided into 2 subgroups, acute inflammatory demyelinating polyradiculoneuropathy (AIDP) and acute motor axonal neuropathy (AMAN), based on electrophysiological information. We found that the TNF\u03b12 allele was associated with increased risk of GBS (OR = 1.876, 95% CI = 1.144\u20133.075, p = 0.008)&lt;i&gt;,&lt;\/i&gt; particularly for AMAN, the main subtype (OR = 2.914, 95% CI = 1.412\u20136.015, p = 0.004), but there was no association between TNF\u03b1 polymorphism and AIDP. We also found that carriers of the TNF\u03b12 allele had significantly higher TNF\u03b12 levels than TNF\u03b11 homozygotes (p &lt; 0.05). These data indicate that TNF\u03b1 promoter polymorphism is responsible for susceptibility to GBS, especially to AMAN. The TNF\u03b12 allele is associated with higher levels of TNF\u03b1.<\/jats:p>","DOI":"10.1159\/000102162","type":"journal-article","created":{"date-parts":[[2007,5,4]],"date-time":"2007-05-04T12:58:39Z","timestamp":1178283519000},"page":"21-25","source":"Crossref","is-referenced-by-count":28,"title":["Association of Tumor Necrosis Factor Polymorphisms with Guillain-Barr\u00e9 Syndrome"],"prefix":"10.1159","volume":"58","author":[{"given":"Jing","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-yan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2007,5,4]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1093%2Fbrain%2F118.3.597"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2805%2967665-9"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2F0022-510X%2892%2990194-P"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093%2Fbrain%2F118.4.869"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.410330606"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0161-5890%2897%2900052-7"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.94.7.3195"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038%2F371508a0"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159%2F000070855"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.410270707"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.410440517"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-510X%2899%2900328-7"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2249.1998.00662.x"}],"container-title":["European Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/102162","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/102162","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:30:37Z","timestamp":1745461837000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000102162"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":13,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2007,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000102162","archive":["Portico"],"relation":{},"ISSN":["0014-3022","1421-9913"],"issn-type":[{"value":"0014-3022","type":"print"},{"value":"1421-9913","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007]]}}}