{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T21:07:53Z","timestamp":1788469673798,"version":"build-2803163510"},"reference-count":17,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gyn\u00e4kol Geburtshilfliche Rundsch"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>Die Endometriose ist eine faszinierende und komplexe Erkrankung, welche vor allem durch eine Dysregulation zwischen, durch retrograde Menstruation ins Abdomen gelangte, Endometriumzellen und der peritonealen Fl\u00fcssigkeit entsteht. Erh\u00f6hte Konzentrationen von aktivierten peritonealen Makrophagen, Lymphozyten, spezifischen Zytokinen und Wachstumshormonen in der peritonealen Fl\u00fcssigkeit unterst\u00fctzen diese Hypothese. Die genaue Rolle dieser verschiedenen Faktoren ist noch nicht bekannt, sicher ist aber, dass das Wachstum der Endometrioseherde durch ein komplexes Zusammenspiel dieser verschiedenen Faktoren bestimmt wird. Vor allem die Angiogenese (= Gef\u00e4ssneubildung) spielt in diesem Prozess eine wichtige Rolle. In den letzten Jahren konnte eine Vielzahl an Wachstumsfaktoren und Zytokinen identifiziert werden, die chemotaktische, modulatorische oder inhibierende Eigenschaften mit Wirkung auf Endothelien, glatte Muskelzellen und Perizyten besitzen. Die Aussprossung von neuen Blutgef\u00e4ssen aus bestehenden tritt nur dann auf, wenn die lokal angiostimulatorischen Faktoren gegen\u00fcber den angioregressorischen Einfl\u00fcssen \u00fcberwiegen. Diese Ver\u00e4nderung des streng kontrollierten Prozesses scheint eine entscheidende Pr\u00e4misse f\u00fcr die ad\u00e4quate Blutversorgung und das \u00dcberleben der ektopen Endometriumzellen zu sein. Im Folgenden werden einige der wichtigsten Faktoren zusammengefasst, welche in der Entwicklung, im Wachstum und in der Progression der Endometriose eine Schl\u00fcsselrolle einnehmen.<\/jats:p>","DOI":"10.1159\/000102572","type":"journal-article","created":{"date-parts":[[2007,6,22]],"date-time":"2007-06-22T11:07:15Z","timestamp":1182510435000},"page":"113-117","source":"Crossref","is-referenced-by-count":3,"title":["Neues zur Pathophysiologie der Endometriose"],"prefix":"10.1159","volume":"47","author":[{"given":"Corinne","family":"Neukomm","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael D.","family":"Mueller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2007,6,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.fertnstert.2006.04.054"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1210%2Fen.2003-0043"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1086%2F432960"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093%2Fhumrep%2Fdel446"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1055%2Fs-2003-41321"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2004-2064"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159%2F000076374"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0015-0282%2802%2904834-3"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.fertnstert.2004.10.058"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.fertnstert.2006.06.026"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.fertnstert.2005.09.064"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS0015-0282%2800%2901630-7"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2FS0015-0282%2802%2904828-8"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ajog.2005.12.010"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.fertnstert.2004.02.148"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1749-6632.2001.tb03795.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.fertnstert.2004.05.094"}],"container-title":["Gyn\u00e4kologisch-geburtshilfliche Rundschau"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/102572","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/102572","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:34:53Z","timestamp":1745462093000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000102572"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":17,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2007,6,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000102572","archive":["Portico"],"relation":{},"ISSN":["1018-8843","1423-0011"],"issn-type":[{"value":"1018-8843","type":"print"},{"value":"1423-0011","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007]]}}}