{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T06:50:24Z","timestamp":1763967024565,"version":"3.40.4"},"reference-count":17,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2007]]},"abstract":"<i>Background:<\/i> The published incidence of paracetamol cross-reactivity in adults and adolescents with nonsteroidal anti-inflammatory drug (NSAID) reactions is low and all data on such reactions in young children is sparse. The study aim was to characterize the clinical presentation and cross-reactivity with paracetamol in patients with a reported onset of NSAID hypersensitivity before 6 years of age. <i>Methods:<\/i> A retrospective case review was done of patients with cross-reactive hypersensitivity reactions to antipyretic\/analgesic medications from the pediatric allergy clinic of the Kendang Kerbau Hospital, Singapore. Included patients reported the onset of such reactions before 6 years of age. Hypersensitivity was established through a detailed history of recurrent reactions to NSAIDs or an oral provocation test. <i>Results:<\/i> Eighteen patients fulfilled the diagnostic criteria within the study period. Eighty-three percent had cross-reactive reactions with paracetamol. When compared to the group of children with later onset of NSAID hypersensitivity, children with onset before 6 years of age had a significantly increased likelihood of reacting to paracetamol (odds ratio 9.6, 95% confidence interval 1.6\u201358.0, p < 0.05). <i>Conclusion:<\/i> Paracetamol seems to be a major eliciting drug in this group of children.<\/jats:p>","DOI":"10.1159\/000102614","type":"journal-article","created":{"date-parts":[[2007,5,16]],"date-time":"2007-05-16T10:44:07Z","timestamp":1179312247000},"page":"51-56","source":"Crossref","is-referenced-by-count":23,"title":["Hypersensitivity to Paracetamol in Asian Children with Early Onset of Nonsteroidal Anti-Inflammatory Drug Allergy"],"prefix":"10.1159","volume":"144","author":[{"given":"Mona Iancovici","family":"Kidon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woei Kang","family":"Liew","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen Chin","family":"Chiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siok Hoon","family":"Lim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Goh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jenny Poh Lin","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oh Moh","family":"Chay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2007,5,14]]},"reference":[{"doi-asserted-by":"publisher","key":"ref1","DOI":"10.1016%2FS1081-1206%2810%2962221-1"},{"doi-asserted-by":"publisher","key":"ref2","DOI":"10.1542%2Fpeds.104.4.e39"},{"doi-asserted-by":"publisher","key":"ref3","DOI":"10.1073%2Fpnas.162468699"},{"doi-asserted-by":"publisher","key":"ref4","DOI":"10.1136%2Fbmj.328.7437.434"},{"doi-asserted-by":"publisher","key":"ref5","DOI":"10.1111%2Fj.1398-9995.2005.00855.x"},{"doi-asserted-by":"publisher","key":"ref6","DOI":"10.1016%2FS1081-1206%2810%2962748-2"},{"doi-asserted-by":"publisher","key":"ref7","DOI":"10.1542%2Fpeds.2005-0969"},{"doi-asserted-by":"publisher","key":"ref8","DOI":"10.1111%2Fj.1399-3038.2004.00159.x"},{"doi-asserted-by":"publisher","key":"ref9","DOI":"10.1016%2Fj.jaci.2003.12.323"},{"doi-asserted-by":"publisher","key":"ref10","DOI":"10.1046%2Fj.1365-2125.1996.04076.x"},{"doi-asserted-by":"publisher","key":"ref11","DOI":"10.1136%2Fadc.87.6.462"},{"doi-asserted-by":"publisher","key":"ref12","DOI":"10.1007%2Fs00439-004-1082-1"},{"doi-asserted-by":"publisher","key":"ref13","DOI":"10.1620%2Ftjem.208.49"},{"doi-asserted-by":"publisher","key":"ref14","DOI":"10.3346%2Fjkms.2005.20.6.926"},{"doi-asserted-by":"publisher","key":"ref15","DOI":"10.1067%2Fmai.2002.124466"},{"doi-asserted-by":"publisher","key":"ref16","DOI":"10.1016%2FS1081-1206%2810%2962265-X"},{"doi-asserted-by":"publisher","key":"ref17","DOI":"10.1067%2Fmai.2000.107603"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/102614","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/102614","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:35:13Z","timestamp":1745462113000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000102614"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":17,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2007,8,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000102614","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"type":"print","value":"1018-2438"},{"type":"electronic","value":"1423-0097"}],"subject":[],"published":{"date-parts":[[2007]]}}}