{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T02:11:13Z","timestamp":1777947073139,"version":"3.51.4"},"reference-count":0,"publisher":"S. Karger AG","license":[{"start":{"date-parts":[[2007,5,11]],"date-time":"2007-05-11T00:00:00Z","timestamp":1178841600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2007,5,11]],"date-time":"2007-05-11T00:00:00Z","timestamp":1178841600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Confin Neurol"],"abstract":"<jats:p>The effect of a single post-training electroconvulsive shock (ECS) treatment has been shown to effect (1) a retrograde amnesia for avoidance behavior in the mouse, (2) a change in the level and metabolism of brain 5-hydroxytryptamine (5-HT), and (3) an inhibition of regional protein synthesis. Injection of physiological quantities of 5-HT into the hippocampal region was effective incausing a retrograde amnesia and also inhibiting cerebral protein synthesis. This effect appeared specific to 5-HT, as other analogs or amines failed to exert a comparable behavioral effect. An age-dependent effect of the amnesia, 5-HT increment, and inhibition of the protein synthesis was demonstrated in that the 17 day old animal showed a marked resistence to the behavioral and biochemical effects of 5-HT. Several molecular interactions having possible significance for synaptic modulation of changes associated with experimentally induced retrograde amnesia have been considered.<\/jats:p>","DOI":"10.1159\/000102824","type":"journal-article","created":{"date-parts":[[2007,5,14]],"date-time":"2007-05-14T04:50:48Z","timestamp":1179118248000},"page":"1-22","source":"Crossref","is-referenced-by-count":19,"title":["Neuromolecular Modulation of Experimentally-Induced Retrograde Amnesia"],"prefix":"10.1159","author":[{"given":"W.B.","family":"Essman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2007,5,11]]},"container-title":["Confinia Neurologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/102824","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/article-pdf\/doi\/10.1159\/000102824","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T21:52:14Z","timestamp":1777758734000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000102824"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5,11]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1159\/000102824","archive":["Portico"],"relation":{},"ISSN":["0010-5678","2571-7227"],"issn-type":[{"value":"0010-5678","type":"print"},{"value":"2571-7227","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,5,11]]}}}