{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T08:59:56Z","timestamp":1781081996996,"version":"3.54.1"},"reference-count":17,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Urol Int"],"published-print":{"date-parts":[[2007]]},"abstract":"<i>Introduction:<\/i> We investigated the effects of standard oral anticholinergic treatment with tolterodine in children with neurogenic bladder over a 5-year follow-up period and focused on treatment satisfaction, patient compliance and urodynamic parameters. <i>Material and Methods:<\/i> The follow-up consisted of regular visits and urodynamic evaluation at least once a year. The patients or their parents were interviewed to evaluate voiding behavior, as well as factors leading to lower patient compliance and deterioration in urodynamic parameters. <i>Results:<\/i> Of the 43 patients evaluated, 30 (70%) took their anticholinergic medication consistently and 13 (30%) sporadically. The mean bladder capacity was 354.7 ml in the first group but only 214.7 ml in the noncompliant group (p < 0.001). The mean maximal detrusor pressure decreased from 42.2 to 33.6 cm H<sub>2<\/sub>O in the compliant group (p < 0.001) and from 49.7 to 46.4 cm H<sub>2<\/sub>O in the noncompliant group (p = 0.21). The mean detrusor compliance increased from 18.9 to 19.3 ml\/cm H<sub>2<\/sub>O in the compliant group (p = 0.63) and from 11.8 to 12.3 ml\/cm H<sub>2<\/sub>O in the noncompliant group (p = 0.87). Side effects such as dry mouth (11\/13) and dizziness (7\/13) were common in the noncompliant group, whereas only 5\/30 reported dry mouth in the compliant group. <i>Conclusions:<\/i> These data demonstrate the efficacy and tolerability of tolterodine over a long follow-up period. The results are promising in view of the fact that the patients will probably require life-long medication. Nevertheless, anticholinergic side effects still cause some patients to refuse regular medication, which results in a poorer urodynamic outcome.<\/jats:p>","DOI":"10.1159\/000102915","type":"journal-article","created":{"date-parts":[[2007,7,11]],"date-time":"2007-07-11T11:21:40Z","timestamp":1184152900000},"page":"55-59","source":"Crossref","is-referenced-by-count":16,"title":["Long-Term Efficacy of Tolterodine and Patient Compliance in Pediatric Patients with Neurogenic Detrusor Overactivity"],"prefix":"10.1159","volume":"79","author":[{"given":"F.","family":"Christoph","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Moschkowitsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Kempkensteffen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Schostak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Schrader","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2007,7,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0090-4295%2897%2900489-5"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1097%2F01.ju.0000147813.28822.d2"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1442-2042.2004.00871.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-5347%2801%2965238-8"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS0014-2999%2897%2989661-6"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0090-4295%2899%2900477-X"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1464-410X.2001.00084.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-5347%2805%2966576-7"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1464-410X.2003.04085.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.eururo.2003.10.009"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-5347%2801%2964448-3"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097%2F01.ju.0000176622.81796.89"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1345%2Faph.18427"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1007%2Fs003450100226"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2FS0090-4295%2802%2901803-4"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007%2Fs003450100223"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097%2F01.ju.0000085667.05190.ad"}],"container-title":["Urologia Internationalis"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/102915","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/102915","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:38:24Z","timestamp":1745462304000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000102915"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":17,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2007,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000102915","archive":["Portico"],"relation":{},"ISSN":["0042-1138","1423-0399"],"issn-type":[{"value":"0042-1138","type":"print"},{"value":"1423-0399","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007]]}}}