{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:57:54Z","timestamp":1745470674532,"version":"3.40.4"},"reference-count":23,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2007,5,22]],"date-time":"2007-05-22T00:00:00Z","timestamp":1179792000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,5,22]],"date-time":"2007-05-22T00:00:00Z","timestamp":1179792000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron Exp Nephrol"],"abstract":"<jats:p>&lt;i&gt;Background\/Aims:&lt;\/i&gt; We previously demonstrated that angiotensin II (AII) combined with Habu snake venom (HV) induces glomerulonephritis (GN) in rats, with lesions being restricted to the glomeruli 2 days after the administration of both reagents, but the mechanisms inducing GN are unclear. We also indicated a role for hypoxia-inducible factor (HIF)-1\u03b1 in attenuating the progression of GN. However, a role of the von Hippel-Lindau (VHL) protein in GN and mechanisms by which HV regulates the pathogenesis of GN remains unclear. &lt;i&gt;Methods and Results:&lt;\/i&gt; Immunohistochemical analysis revealed that VHL is weakly expressed in the renal tubules alone; however, HV caused elevated VHL expression in the injured glomeruli including endothelial cells and partially podocytes. Western blot analysis revealed that VHL expression was increased in HV-treated kidney compared with AII-treated or normal kidney. An in vitro study also showed HV-induced elevation in VHL expression. To investigate whether VHL pre-induction causes GN aggravation, we utilized thrombin, an inducer of VHL. Thrombin alone did not cause renal injuries; however, thrombin pre-treatment accelerated the development of GN even 1 day after treatment. &lt;i&gt;Conclusion:&lt;\/i&gt; We suggest that VHL pre-induction by thrombin aggravates GN, and that the increase in VHL expression due to HV might be involved in accelerating onset of GN.<\/jats:p>","DOI":"10.1159\/000103022","type":"journal-article","created":{"date-parts":[[2007,5,29]],"date-time":"2007-05-29T08:47:23Z","timestamp":1180428443000},"page":"e97-e106","source":"Crossref","is-referenced-by-count":3,"title":["Modification in the von Hippel-Lindau Protein Is Involved in the Progression of Experimentally Induced Rat Glomerulonephritis"],"prefix":"10.1159","volume":"106","author":[{"given":"Yoshihiro","family":"Kudo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshihiko","family":"Kakinuma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuko","family":"Iguchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takayuki","family":"Sato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuro","family":"Sugiura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mutsuo","family":"Furihata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taro","family":"Shuin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2007,5,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159%2F000084575"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038%2F20459"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.1073440"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.semnephrol.2003.11.002"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1177%2F019262339802600106"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002%2Fijc.20468"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038%2Fki.1984.147"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.febslet.2005.02.065"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097%2F00004647-200109000-00008"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1097%2F01.ASN.0000074239.22357.06"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1471-4159.2005.03032.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1038%2Fnm723"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.M209114200"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1161%2Fhh1301.092678"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002%2Fjcp.1041460117"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1749-6632.1986.tb34587.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1084%2Fjem.191.3.455"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMra020528"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfl340"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1681%2FASN.2005080810"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1152%2Fajprenal.00146.2004"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.2337%2Fdiabetes.54.6.1626"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.M403687200"}],"container-title":["Nephron Experimental Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/103022","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/103022","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:39:29Z","timestamp":1745462369000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000103022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5,22]]},"references-count":23,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2007,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000103022","archive":["Portico"],"relation":{},"ISSN":["1660-2129"],"issn-type":[{"type":"electronic","value":"1660-2129"}],"subject":[],"published":{"date-parts":[[2007,5,22]]}}}