{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:57:57Z","timestamp":1745470677264,"version":"3.40.4"},"reference-count":8,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cerebrovasc Dis"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; A disruption of the extracellular matrix (ECM) of the intracranial arterial wall is a likely contributing factor in the pathogenesis of intracranial aneurysms. If this is a generalized process, patients with subarachnoid haemorrhage (SAH) may have subtle signs of a general laxity of the connective tissue. We performed a pilot study to assess general laxity in SAH patients and to examine which tests for joint mobility can be best used in these patients. &lt;i&gt;Methods:&lt;\/i&gt; In 59 SAH patients and sex- and age-matched controls we compared: (1) joint mobility (scores of Beighton and Bulbena and the total range of joint motion); (2) skin extensibility, and (3) bone quantity and stiffness. For the analyses we used the independent-samples T test and linear regression with adjustment for possible confounders. &lt;i&gt;Results:&lt;\/i&gt; The patients had a higher degree of joint mobility according to the Beighton criteria (total score of 4 in patients vs. 2 in controls, p = 0.001) and the summation of Z scores of active range of motion measurements (0.1 in patients vs. \u20130.1 in controls, p = 0.0036), and a tendency towards a higher degree of joint mobility according to the Bulbena criteria (total score of 3 in patients vs. 2 in controls, p = 0.097) and the summation of active range of joint motion measurements (1,292 in patients vs. 1,275 in controls, p = 0.13). No differences were found for the other investigated characteristics. &lt;i&gt;Conclusions:&lt;\/i&gt; Our preliminary results suggest that SAH patients have a higher degree of joint mobility than controls. The Beighton score can be best used in our patient population.<\/jats:p>","DOI":"10.1159\/000103116","type":"journal-article","created":{"date-parts":[[2007,5,29]],"date-time":"2007-05-29T08:47:23Z","timestamp":1180428443000},"page":"51-55","source":"Crossref","is-referenced-by-count":1,"title":["Searching for Subtle Features of Laxity of Connective Tissue in Patients with Ruptured Intracranial Aneurysms: A Pilot Study"],"prefix":"10.1159","volume":"24","author":[{"given":"Rob H.A.","family":"Wolswijk","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ynte M.","family":"Ruigrok","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel J.E.","family":"Rinkel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eva H.","family":"Brilstra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raoul H.H.","family":"Engelbert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2007,5,22]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111%2F1523-1747.ep12319926"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2805%2967789-6"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038%2F352337a0"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1136%2Fard.32.5.413"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.3109%2F09593989309036492"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.19.5.604"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.3109%2F03008208609001974"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1053%2Fejvs.2000.1180"}],"container-title":["Cerebrovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/103116","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/103116","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:40:27Z","timestamp":1745462427000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000103116"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":8,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2007,6,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000103116","archive":["Portico"],"relation":{},"ISSN":["1015-9770","1421-9786"],"issn-type":[{"type":"print","value":"1015-9770"},{"type":"electronic","value":"1421-9786"}],"subject":[],"published":{"date-parts":[[2007]]}}}