{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T23:48:12Z","timestamp":1770508092778,"version":"3.49.0"},"reference-count":27,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2007]]},"abstract":"<i>Background:<\/i> Local reactions (LRs) are a very frequent side effect of specific immunotherapy with allergens and can impair patients\u2019 adherence. Antihistamine pretreatment \u2013 originally introduced as a safety measure to reduce anaphylactic side effects \u2013 has been the only treatment option for LRs so far, although these swellings usually do not appear immediately but after hours. We were interested whether pretreatment with the leukotriene antagonist montelukast would be better suited for preventing those reactions than pretreatment with the antihistamine desloratadine. <i>Methods:<\/i> Fifteen patients with a history of severe anaphylactic reactions to hymenoptera stings were enrolled into a prospective, double-blind, randomized, placebo-controlled pilot study. We selected a rush immunotherapy protocol consisting of 19 injections of hymenoptera venom administered over 5 consecutive days, where the majority is developing LRs, and counted the number of injections until an LR of >3 cm occurred. The patients were randomized to 3 treatment groups: premedication with placebo, 10 mg montelukast and 5 mg of the antihistamine desloratadine. <i>Results:<\/i> Compared with placebo, the occurrence of LRs (>3 cm) was significantly delayed by montelukast (p < 0.01, analysis of variance) but not by desloratadine (p = 0.19). The difference between montelukast and desloratadine was close to significant (p = 0.054). Itching, recorded on a scale from 0 to 5, did not differ between the 3 groups. <i>Conclusion:<\/i> Montelukast can be useful in the prevention of LRs after specific immunotherapy.<\/jats:p>","DOI":"10.1159\/000103225","type":"journal-article","created":{"date-parts":[[2007,5,25]],"date-time":"2007-05-25T13:05:53Z","timestamp":1180098353000},"page":"137-142","source":"Crossref","is-referenced-by-count":47,"title":["Premedication with Montelukast Reduces Local Reactions of Allergen Immunotherapy"],"prefix":"10.1159","volume":"144","author":[{"given":"Stefan","family":"W\u00f6hrl","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simon","family":"Gamper","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wolfgang","family":"Hemmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg","family":"Heinze","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georg","family":"Stingl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamar","family":"Kinaciyan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2007,5,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0149-2918%2800%2980039-9"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa022952"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaci.2004.07.046"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1398-9995.2005.00960.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1067%2Fmai.2002.129124"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1398-9995.2000.00587.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2222.1992.tb00115.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0091-6749%2896%2970186-0"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2FS0091-6749%2897%2970135-0"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1398-9995.2000.00520.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1398-9995.1997.tb02551.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1097%2F01.all.0000136754.13077.fc"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2FS1081-1206%2810%2962354-X"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2567.2005.02276.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2FS0194-5998%2803%2900607-7"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1067%2Fmai.2003.1559"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2222.2001.01189.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2222.2004.02019.x"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007%2Fs11882-004-0009-1"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2FS0091-6749%2802%2981267-2"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016%2FS0091-6749%2802%2981643-8"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1067%2Fmai.2000.110468"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.3109%2F02770906609106941"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016%2F0091-6749%2892%2990319-W"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaci.2003.12.591"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaci.2004.06.018"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1067%2Fmai.2001.111852"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/103225","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/103225","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:41:55Z","timestamp":1745462515000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000103225"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":27,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2007,9,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000103225","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"value":"1018-2438","type":"print"},{"value":"1423-0097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007]]}}}