{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:10:39Z","timestamp":1761487839615,"version":"3.40.4"},"reference-count":14,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2007]]},"abstract":"<i>Background:<\/i> Gadolinium chelates are relatively safe contrast media used in MRI. Immediate severe adverse effects are exceptionally rare and mostly concern mild anaphylactoid reactions. We report a case of anaphylaxis to gadobenate dimeglumine (Gd-BOPTA, Multihance\u00ae), a gadolinium-based contrast agent. <i>Methods:<\/i> A 32-year-old female patient with a personal history of multiple sclerosis, while undergoing an MRI scan, developed bronchospasm and acute urticaria with diffuse giant pruritic plaques in the first minute of Gd-BOPTA infusion. The procedure was cancelled and acute treatment of the reaction took place. The patient reported 2 additional MRI scans with definite use of unknown contrast media in the past 2 years without any adverse effect. Blood samples were obtained 2 and 48 h after the reaction for measurement of serum tryptase concentration (Pharmacia Diagnostics, Uppsala, Sweden). Skin prick tests and intradermal tests were performed using 1:1,000, 1:100 and 1:10 dilution of the offending agent and alternative gadolinium-based agents [gadodiamide (Omniscan\u00ae) and gadoteric acid (Dotarem\u00ae)]. A group of 10 nonatopic individuals who underwent the same skin testing comprised the control group. <i>Results:<\/i> Tryptase concentration was highly elevated 2 h after the reaction (21 \u00b5g\/l) compared with that at 48 h (3 \u00b5g\/l). Skin prick tests in our patient were all negative, while intradermal testing with 0.03 ml of 1:100 and 1:10 preparations of Multihance showed a definite positive wheal-and-flare reaction. Skin tests to the alternative agents showed no response. In the control group, all performed tests were negative. <i>Conclusion:<\/i> We report the first case of an allergic reaction to gadobenate dimeglumine. Besides, skin testing seems to be a precious diagnostic tool which, if positive, strongly suggests a mast cell-mediated underlying mechanism.<\/jats:p>","DOI":"10.1159\/000103227","type":"journal-article","created":{"date-parts":[[2007,5,25]],"date-time":"2007-05-25T13:05:53Z","timestamp":1180098353000},"page":"150-154","source":"Crossref","is-referenced-by-count":32,"title":["Anaphylaxis to Gadobenate Dimeglumine (Multihance\u00ae): A Case Report"],"prefix":"10.1159","volume":"144","author":[{"given":"Dimitrios C.","family":"Kalogeromitros","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael P.","family":"Makris","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xenophon S.","family":"Aggelides","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nektaria","family":"Spanoudaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stamatios G.","family":"Gregoriou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgia","family":"Avgerinou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitrios G.","family":"Rigopoulos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2007,5,25]]},"reference":[{"doi-asserted-by":"publisher","key":"ref1","DOI":"10.1111%2Fj.1398-9995.2005.00745.x"},{"doi-asserted-by":"publisher","key":"ref2","DOI":"10.1016%2Fj.tox.2005.01.010"},{"doi-asserted-by":"publisher","key":"ref3","DOI":"10.1034%2Fj.1398-9995.2001.056003250.x"},{"doi-asserted-by":"publisher","key":"ref4","DOI":"10.1111%2Fj.1365-2222.2006.02532.x"},{"doi-asserted-by":"publisher","key":"ref5","DOI":"10.1097%2F00002142-200310000-00007"},{"doi-asserted-by":"publisher","key":"ref6","DOI":"10.1002%2F%28SICI%291522-2586%28199909%2910%3A3%3C477%3A%3AAID-JMRI33%3E3.0.CO%3B2-E"},{"doi-asserted-by":"publisher","key":"ref7","DOI":"10.1016%2FS1076-6332%2898%2980069-X"},{"doi-asserted-by":"publisher","key":"ref8","DOI":"10.1097%2F01.rli.0000209661.99225.c2"},{"doi-asserted-by":"publisher","key":"ref9","DOI":"10.1002%2Fjmri.1184"},{"doi-asserted-by":"publisher","key":"ref10","DOI":"10.1034%2Fj.1600-0536.2001.450601.x"},{"doi-asserted-by":"publisher","key":"ref11","DOI":"10.1034%2Fj.1398-9995.2002.13027.x"},{"doi-asserted-by":"publisher","key":"ref12","DOI":"10.1016%2Fj.fertnstert.2005.06.032"},{"doi-asserted-by":"publisher","key":"ref13","DOI":"10.1007%2Fs10016-001-0273-7"},{"doi-asserted-by":"publisher","key":"ref14","DOI":"10.1259%2Fbjr%2F88469693"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/103227","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/103227","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:41:56Z","timestamp":1745462516000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000103227"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":14,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2007,9,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000103227","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"type":"print","value":"1018-2438"},{"type":"electronic","value":"1423-0097"}],"subject":[],"published":{"date-parts":[[2007]]}}}