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Karger AG","issue":"2-3","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>This study was designed to investigate whether atorvastatin has a beneficial effect on left ventricular (LV) remodeling in spontaneously hypertensive rats (SHR), and then explore the underlying mechanisms involved. 12 SHRs were randomized to receive either distilled water (SHR group, n = 6) or atorvastatin (ATV group, n = 6) for 10 weeks. Age-matched Wistar-Kyoto rats (WKY) gavaged by distilled water were used as normal controls (WKY group, n = 6). By using these rats, we observed the effects of atorvastatin on LV hypertrophy and fibrosis, and investigated atorvastatin-induced cell apoptosis and p27 protein expression. In addition, the serum lipid concentration and blood pressure level were also measured in this study. 10 weeks later, a significant decrease in the cardiosomatic ratio, LV weight to body weight ratio and cardiomyocyte transverse diameter, as well as myocardial hydroxyproline and collagen content was observed in the atorvastatin-treated SHR. In addition, atorvastatin increased the positive rate of cell apoptosis and p27 protein expression. A decreased serum lipid concentration and a reduced systolic blood pressure level were also found in the atorvastatin-treated SHR. These findings demonstrated a beneficial effect of atorvastatin on adverse LV remodeling in SHR, and the induction of cell apoptosis and upregulation of p27 protein may serve as the underlying mechanisms of this action.<\/jats:p>","DOI":"10.1159\/000103251","type":"journal-article","created":{"date-parts":[[2007,5,30]],"date-time":"2007-05-30T12:08:42Z","timestamp":1180526922000},"page":"120-126","source":"Crossref","is-referenced-by-count":9,"title":["Beneficial Effect of Atorvastatin on Left Ventricular Remodeling in Spontaneously Hypertensive Rats"],"prefix":"10.1159","volume":"80","author":[{"given":"Lan","family":"Kang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chang-Jiang","family":"Ge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shen-Jiang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2007,5,29]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI118747"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007%2Fs001090050275"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0895-7061%2899%2900213-7"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1096%2Ffj.01-0130com"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1023%2FB%3AJOMG.0000023589.00994.5e"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002%2Fclc.4960180605"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2FS0167-5273%2802%2900368-6"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1291%2Fhypres.25.279"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2FS0021-9150%2800%2900764-4"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.1999.07122.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-2828%2803%2900180-9"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1253%2Fcircj.68.121"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1161%2Fhc2801.094031"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI5339"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2FS0008-6363%2800%2900152-8"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.M204716200"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2FS0167-5273%2802%2900588-0"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ctrv.2004.06.010"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ejphar.2005.05.009"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2FS0021-9150%2801%2900613-X"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.274.31.21926"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1161%2F01.RES.0000099503.13312.7B"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ahj.2005.02.033"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1097%2F00005344-200004000-00006"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1081%2FJDI-200056610"}],"container-title":["Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/103251","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/103251","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:42:12Z","timestamp":1745462532000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000103251"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":25,"journal-issue":{"issue":"2-3","published-online":{"date-parts":[[2007,8,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000103251","archive":["Portico"],"relation":{},"ISSN":["0031-7012","1423-0313"],"issn-type":[{"type":"print","value":"0031-7012"},{"type":"electronic","value":"1423-0313"}],"subject":[],"published":{"date-parts":[[2007]]}}}