{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T23:11:49Z","timestamp":1790291509874,"version":"4.1.0"},"reference-count":46,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Bilirubin encephalopathy or kernicterus is a potentially serious complication of neonatal hyperbilirubinemia. The mechanism of bilirubin-induced neurotoxicity is not known. Many neurological insults are mediated through NMDA receptor activation. &lt;i&gt;Objective:&lt;\/i&gt; We assessed the effect of the NMDA channel antagonist, MK-801 on bilirubin neurotoxicity in vivo and in vitro. &lt;i&gt;Methods:&lt;\/i&gt; Bilirubin toxic ity in vitro was assessed using trypan blue staining. Sulfadimethoxine injected (i.p.) jaundiced Gunn rat pups ex hibit many neurological sequelae observed in human hyperbilirubinemia. Brainstem auditory-evoked potentials (BAEPs), a noninvasive sensitive tool to assess auditory dysfunction due to bilirubin neurotoxicity, were used to assess neuroprotection with MK-801 (i.p.) in vivo. &lt;i&gt;Results:&lt;\/i&gt; In primary cultures of hippocampal neurons, 20 min exposure to 64:32 \u00b5&lt;i&gt;M&lt;\/i&gt; bilirubin:human serum albumin reduced the cell viability by approximately 50% ten hours later. MK-801 treatment did not protect the cells. MK-801 pretreatment doses ranging from 0.1\u20134.0 mg\/kg did not protect against BAEP abnormalities in Gunn rat pups 6 h after sulfadimethoxine injection. &lt;i&gt;Conclusion:&lt;\/i&gt; Our findings suggest that bilirubin neurotoxicity is not mediated through NMDA receptor activation.<\/jats:p>","DOI":"10.1159\/000103743","type":"journal-article","created":{"date-parts":[[2007,6,8]],"date-time":"2007-06-08T11:11:53Z","timestamp":1181301113000},"page":"248-257","source":"Crossref","is-referenced-by-count":19,"title":["NMDA Channel Antagonist MK-801 Does Not Protect against Bilirubin Neurotoxicity"],"prefix":"10.1159","volume":"92","author":[{"given":"Steven M.","family":"Shapiro","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sompong","family":"Sombati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Geiger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann 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