{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:02:22Z","timestamp":1787313742310,"version":"build-2736575974"},"reference-count":38,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dig Dis"],"published-print":{"date-parts":[[2007]]},"abstract":"<i>Background:<\/i> Non-invasive methods are advisable for the detection of <i>Helicobacter pylori-<\/i>related chronic gastritis in pediatric patients. Serum pepsinogens I and II (sPGII and sPGII), gastrin-17 (G-17) and anti-<i>H. pylori<\/i> antibodies (IgG-<i>Hp<\/i>) have been proposed as a \u2018serological gastric biopsy\u2019. <i>Aim:<\/i> To assess <i>H. pylori<\/i> infection and to evaluate gastric mucosa status in a pediatric population by means of serological parameters such as sPGI, sPGII, G-17 and IgG-<i>Hp<\/i>. <i>Methods:<\/i> 45 consecutively children evaluated for upper gastrointestinal symptoms were analyzed. All children were submitted to upper gastrointestinal endoscopy with biopsies. Serum samples were analyzed for IgG-<i>Hp<\/i>, sPGII, sPGI and G-17 (Biohit, Helsinki, Finland). <i>Results:<\/i> 18 children had <i>H. pylori-<\/i>related mild or moderate non-atrophic chronic gastritis. They presented significantly higher mean levels of sPGII and of IgG-<i>Hp<\/i> than negative ones, eitherunder or up to 10 years. sPGI showed significantly increased levels in <i>H. pylori-<\/i>positive patients only over 10 years. G-17 levels were not different between <i>H. pylori-<\/i>positive and -negative ones. The best cut-offs of IgG-<i>Hp<\/i>, sPGII and of product IgG-<i>Hp<\/i>\u00b7sPGII, to identify <i>H. pylori <\/i>infection<i>, <\/i>were 30 IU\/l, 9 \u00b5g\/l, and 241 IU\/l\u00b7\u00b5g\/l, respectively. The product IgG-<i>Hp<\/i>\u00b7sPGII identified <i>H. pylori<\/i> infection with a 100% sensitivity, 92% specificity, 90% positive predictive value and 100% negative predictive value. IgG-<i>Hp<\/i> and IgG-<i>Hp<\/i> showed a correlation (r = 0.94; p < 0.001). <i>Conclusions:<\/i> Combined analysis of sPGII and IgG-<i>Hp<\/i> antibody levels could be recommended as a non-invasive panel for the assessment of <i>H. pylori-<\/i>related histological alterations of gastric mucosa in childhood.<\/jats:p>","DOI":"10.1159\/000103886","type":"journal-article","created":{"date-parts":[[2007,9,10]],"date-time":"2007-09-10T04:41:19Z","timestamp":1189399279000},"page":"206-213","source":"Crossref","is-referenced-by-count":27,"title":["Usefulness of a Serological Panel Test in the Assessment of Gastritis in Symptomatic Children"],"prefix":"10.1159","volume":"25","author":[{"given":"Gian Luigi","family":"De Angelis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas 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