{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T15:44:11Z","timestamp":1758123851323,"version":"3.40.4"},"reference-count":24,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2007]]},"abstract":"Some adolescents with a history of idiopathic central precocious puberty (ICPP) develop hyperandrogenism. <i>Hypothesis:<\/i> Luteinizing hormone (LH) hypersecretion could be a common mechanism underlying ICPP and polycystic ovary syndrome. <i>Aim:<\/i> To explore the GnRH-LH axis in those patients. <i>Design:<\/i> To compare overnight LH secretion in 7 healthy adolescents (CG) with that in patients with prior ICPP [5 with (CPPA) and 7 without (CPPB) hyperandrogenism]. To analyze daytime LH secretion in those patients. <i>Methods:<\/i> LH secretion was quantified by immunofluorometry and deconvolution analysis. <i>Results:<\/i> Nighttime mean LH (international units\/liter) was higher in CPPA (6.9 \u00b1 1.5) than in CPPB (3.2 \u00b1 0.4, p < 0.05) and CG (2.9 \u00b1 0.4, p < 0.01). Deconvolution analysis revealed a greater nighttime LH frequency (pulses\/hour) both in CPPA (0.91 \u00b1 0.06, p < 0.01) and CPPB (0.74 \u00b1 0.02, p < 0.05) than in CG (0.45 \u00b1 0.07). CPPA patients maintained a higher frequency than CPPB. Pulsatile LH production was greater in CPPA than in CG (50 \u00b1 12 vs. 18 \u00b1 3 IU\/l\/day, p < 0.01). Daytime mass of LH released per burst and pulsatile production rate were significantly greater in CPPA than in CPPB patients. <i>Conclusions:<\/i> Hyperandrogenic adolescents with prior ICPP show increased pulsatile LH secretion. Augmentation of LH pulsatility may predispose to or cause hyperandrogenism in some adolescents with a history of precocious puberty.<\/jats:p>","DOI":"10.1159\/000104177","type":"journal-article","created":{"date-parts":[[2007,6,22]],"date-time":"2007-06-22T11:07:15Z","timestamp":1182510435000},"page":"278-285","source":"Crossref","is-referenced-by-count":4,"title":["Acceleration of Luteinizing Hormone Pulse Frequency in Adolescent Girls with a History of Central Precocious Puberty with versus without Hyperandrogenism"],"prefix":"10.1159","volume":"68","author":[{"given":"Mar\u00eda Eugenia","family":"Escobar","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Gabriela","family":"Ropelato","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Gabriela","family":"Ballerini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirta Graciela","family":"Gryngarten","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Cecilia","family":"Garc\u00eda Rudaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes D.","family":"Veldhuis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Barontini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2007,6,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1159%2F000182288"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2F0929-693X%2896%2981241-3"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1530%2Feje.0.1330407"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1530%2Feje.0.1390621"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1210%2Fjcem-21-11-1440"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2265.1989.tb03739.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159%2F000185508"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2F0076-6879%2892%2910028-C"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.88.6.2297"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.84.12.4583"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2005-2153"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2005-2501"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2006-0178"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.83.9.3078"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2265.1999.00886.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.85.7.2434"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2003-032046"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2005-2430"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.76.4.940"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM198311173092002"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.79.1.119"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1055%2Fs-2002-36706"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.2004-2359"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1093%2Fhumupd%2Fdml017"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/104177","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/104177","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:52:52Z","timestamp":1745463172000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000104177"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":24,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2007,11,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000104177","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"type":"print","value":"1663-2818"},{"type":"electronic","value":"1663-2826"}],"subject":[],"published":{"date-parts":[[2007]]}}}