{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T16:37:40Z","timestamp":1768322260977,"version":"3.49.0"},"reference-count":16,"publisher":"S. Karger AG","issue":"2-3","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cerebrovasc Dis"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; This study is designed to determine the relationship between age and occurrence of cerebral manifestations of small-vessel ischemic vascular disease in human immunodeficiency virus (HIV)-seropositive individuals. &lt;i&gt;Methods:&lt;\/i&gt; Periventricular leukoaraiosis severity and white matter lesion volume were determined by magnetic resonance imaging of the brain of 57 HIV-seropositive individuals. &lt;i&gt;Results:&lt;\/i&gt; Cerebral small-vessel ischemic vascular disease manifestations correlated with age and systolic blood pressure, but not with HIV infection-related parameters. &lt;i&gt;Conclusions:&lt;\/i&gt; These findings suggest that, in the era of highly active antiretroviral therapy, leukoaraiosis severity and white matter lesion volume may be more indicative of small-vessel ischemic vascular disease than HIV-related CNS pathology, and support the need for aggressive treatment of vascular risk factors in HIV-seropositive individuals.<\/jats:p>","DOI":"10.1159\/000104484","type":"journal-article","created":{"date-parts":[[2007,6,29]],"date-time":"2007-06-29T09:43:10Z","timestamp":1183110190000},"page":"236-241","source":"Crossref","is-referenced-by-count":41,"title":["Small-Vessel Vascular Disease in Human Immunodeficiency Virus Infection: The Hawaii Aging with HIV Cohort Study"],"prefix":"10.1159","volume":"24","author":[{"given":"Aaron","family":"McMurtray","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beau","family":"Nakamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecelia","family":"Shikuma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Victor","family":"Valcour","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2007,6,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0895-4356%2801%2900445-0"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.0000080934.68280.82"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159%2F000091536"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159%2F000093235"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1001%2Farchneur.55.9.1217"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.0000052631.98405.15"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1136%2Fjnnp.70.1.9"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS1474-4422%2802%2900190-4"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002%2F1531-8249%28200002%2947%3A2%3C145%3A%3AAID-ANA3%3E3.0.CO%3B2-P"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.10294"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1161%2F01.STR.0000133686.29320.58"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2874%2991496-2"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1136%2Fjnnp.65.3.301"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2FS0925-4927%2800%2900082-2"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1080%2F13550280590953799"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jneuroim.2004.08.043"}],"container-title":["Cerebrovascular Diseases"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/104484","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/104484","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:55:34Z","timestamp":1745463334000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000104484"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":16,"journal-issue":{"issue":"2-3","published-online":{"date-parts":[[2007,8,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000104484","archive":["Portico"],"relation":{},"ISSN":["1015-9770","1421-9786"],"issn-type":[{"value":"1015-9770","type":"print"},{"value":"1421-9786","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007]]}}}