{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:58:45Z","timestamp":1745470725066,"version":"3.40.4"},"reference-count":17,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Eur Neurol"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>&lt;i&gt;Background\/Aims:&lt;\/i&gt; Degenerative lower motor neuron diseases (LMND) encompass a group of rare clinically and genetically heterogeneous disorders with the hallmark of anterior horn cell degeneration in the spinal cord and brainstem. In a recently proposed classification, LMND were subdivided according to the clinical disease pattern and time course. This study was performed to investigate the clinical practicability of the classification. &lt;i&gt;Methods:&lt;\/i&gt; In 22 patients with adult LMND (mean disease duration, 24 years), the disease course and detailed clinical, electrophysiological, magnetic resonance imaging, laboratory, and genetic investigations were analyzed. &lt;i&gt;Results:&lt;\/i&gt; All patients could be assigned to the distinct disease subgroups, i.e. 11 patients to the slowly progressive generalized form (group 1), one to the distal form (group 2), 3 to the segmental distal form (group 3a), and seven to the segmental proximal form (group 3b). &lt;i&gt;Conclusions:&lt;\/i&gt; The proposed classification was confirmed to be a practicable tool, and additional implications for the classification of LMND could be drawn from the data in our patient sample.<\/jats:p>","DOI":"10.1159\/000104719","type":"journal-article","created":{"date-parts":[[2007,7,4]],"date-time":"2007-07-04T14:10:31Z","timestamp":1183558231000},"page":"170-176","source":"Crossref","is-referenced-by-count":6,"title":["Classification of Phenotype Characteristics in Adult-Onset Spinal Muscular Atrophy"],"prefix":"10.1159","volume":"58","author":[{"given":"Hans-J\u00fcrgen","family":"Gdynia","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne-Dorte","family":"Sperfeld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonie","family":"Flaith","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Kuehnlein","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Unrath","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert C.","family":"Ludolph","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Kassubek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2007,6,29]]},"reference":[{"doi-asserted-by":"publisher","key":"ref1","DOI":"10.1002%2Fana.410080219"},{"doi-asserted-by":"publisher","key":"ref2","DOI":"10.1017%2FS0022215100053184"},{"doi-asserted-by":"publisher","key":"ref3","DOI":"10.1055%2Fs-2008-1040858"},{"doi-asserted-by":"publisher","key":"ref4","DOI":"10.1212%2F01.wnl.0000205597.62054.db"},{"doi-asserted-by":"publisher","key":"ref5","DOI":"10.1002%2Fana.20468"},{"doi-asserted-by":"publisher","key":"ref6","DOI":"10.1093%2Fbrain%2Fawg117"},{"doi-asserted-by":"publisher","key":"ref7","DOI":"10.1007%2Fs004150050397"},{"doi-asserted-by":"publisher","key":"ref8","DOI":"10.1159%2F000084650"},{"doi-asserted-by":"publisher","key":"ref9","DOI":"10.1093%2Fhmg%2F4.10.1927"},{"doi-asserted-by":"publisher","key":"ref10","DOI":"10.1038%2F362059a0"},{"doi-asserted-by":"publisher","key":"ref11","DOI":"10.1007%2F978-3-540-34449-0_6"},{"doi-asserted-by":"publisher","key":"ref12","DOI":"10.1016%2F0022-510X%2883%2990082-5"},{"doi-asserted-by":"publisher","key":"ref13","DOI":"10.1159%2F000115539"},{"doi-asserted-by":"publisher","key":"ref14","DOI":"10.1111%2Fj.1600-0404.2005.00428.x"},{"doi-asserted-by":"publisher","key":"ref15","DOI":"10.1097%2F01.wco.0000183114.76056.0e"},{"doi-asserted-by":"publisher","key":"ref16","DOI":"10.1212%2F01.wnl.0000223315.62404.00"},{"doi-asserted-by":"publisher","key":"ref17","DOI":"10.1016%2F0022-510X%2891%2990284-E"}],"container-title":["European Neurology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/104719","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/104719","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:57:47Z","timestamp":1745463467000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000104719"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":17,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2007,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000104719","archive":["Portico"],"relation":{},"ISSN":["0014-3022","1421-9913"],"issn-type":[{"type":"print","value":"0014-3022"},{"type":"electronic","value":"1421-9913"}],"subject":[],"published":{"date-parts":[[2007]]}}}