{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T18:46:52Z","timestamp":1778352412291,"version":"3.51.4"},"reference-count":18,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Ophthalmologica"],"published-print":{"date-parts":[[2007]]},"abstract":"<i>Aims:<\/i> Primary non-Hodgkin\u2019s lymphoma (NHL) of the orbit is uncommon, representing approximately 8% of extranodal NHLs. Twenty-two patients with indolent stage IE NHL were reviewed retrospectively to analyze the outcome and late effects of primary local radiotherapy. <i>Materials and Methods:<\/i> The median age at first diagnosis was 63.5 years (range 24\u201382 years). Extranodal mucosa-associated lymphoid tissue lymphoma (n = 15) was the most common histological subtype of NHL, followed by follicular (n = 6) and lymphoplasmacytic lymphoma (n = 1). Radiotherapy was performed using a linear accelerator. The median radiation dose was 40 Gy (range 30\u201346 Gy). None of the patients received chemotherapy before irradiation. The follow-up period was 62 months (range 8\u2013136 months). <i>Results:<\/i>A complete response was achieved in all patients. The 5-year local control rate was 100%. Distant relapse occurred in 2 patients, resulting in a 5-year distant relapse-free survival rate of 88%. The 5-year overall survival rate was 89%; there were no lymphoma-related deaths. No serious acute complications (grade 3\/4) were observed. Grade 1\/2 late effects were documented in 44% of patients. Grade 3 complications (cataract: 2, dryness: 2) were observed in 4 patients (18%). <i>Conclusions:<\/i> Indolent early stage orbital NHL can be controlled with local radiotherapy. Morbidity is low. Regular follow-up examinations are necessary to detect rare cases of distant relapse.<\/jats:p>","DOI":"10.1159\/000104766","type":"journal-article","created":{"date-parts":[[2007,8,29]],"date-time":"2007-08-29T09:18:51Z","timestamp":1188379131000},"page":"348-352","source":"Crossref","is-referenced-by-count":7,"title":["Indolent Stage IE Non-Hodgkin\u2019s Lymphoma of the Orbit: Results after Primary Radiotherapy"],"prefix":"10.1159","volume":"221","author":[{"given":"M.","family":"Bischof","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Zierhut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Neuhof","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Karagiozidis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Treiber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Roeder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Debus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Krempien","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2007,8,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0360-3016%2802%2902966-8"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0167-8140%2800%2900328-5"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0360-3016%2801%2902729-8"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00277-004-0914-3"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1023%2FA%3A1008383406103"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.clon.2003.10.010"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.clon.2004.10.007"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.2307%2F2281868"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2F0360-3016%2895%2900062-4"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2F0167-8140%2891%2990067-Q"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS0360-3016%2898%2900535-5"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2F0167-8140%2895%2901658-9"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2FS0360-3016%2803%2900767-3"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2FS0360-3016%2802%2904159-7"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2F0360-3016%2894%2900416-1"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2FS0936-6555%2803%2900250-4"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.clon.2004.07.004"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2FS0360-3016%2803%2900506-6"}],"container-title":["Ophthalmologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/104766","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/104766","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:58:17Z","timestamp":1745463497000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000104766"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":18,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2007,8,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000104766","archive":["Portico"],"relation":{},"ISSN":["0030-3755","1423-0267"],"issn-type":[{"value":"0030-3755","type":"print"},{"value":"1423-0267","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007]]}}}