{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T00:40:28Z","timestamp":1790642428081,"version":"4.1.0"},"reference-count":21,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney Blood Press Res"],"published-print":{"date-parts":[[2007]]},"abstract":"<i>Background\/Aims:<\/i> Rapamycin inhibits cyst growth in polycystic kidney disease by targeting the mammalian target of rapamycin (mTOR). To determine if this is a class effect of the mTOR inhibitors, we examined the effect of everolimus, the analogue of rapamycin, on disease progression in the Han:SPRD rat model of polycystic kidney disease. <i>Methods:<\/i> Four-week-old male heterozygous cystic (Cy\/+) and wild-type normal (+\/+) Han:SPRD rats were administered everolimus or vehicle (3 mg\/kg\/day) by gavage for 5 weeks. Kidney function and whole-blood trough levels of everolimus were monitored. After treatment kidney weight and cyst volume density were assessed. Tubule epithelial cell proliferation was assessed by BrdU staining. <i>Results:<\/i> Everolimus trough levels between 5 and 7 \u00b5g\/l were sufficient to significantly reduce kidney and cyst volume density by approximately 50 and 40%, respectively. The steady decrease of kidney function in Cy\/+ rats was reduced by 30% compared with vehicle-treated Cy\/+ rats. Everolimus treatment markedly reduced the number of 5-bromo-2-deoxyuridine-labeled nuclei in cyst epithelia. Body weight gain and kidney function were impaired in everolimus-treated wild-type rats. <i>Conclusion:<\/i> Moderate dosage of everolimus inhibits cystogenesis in Han:SPRD rats. The inhibitory effect of everolimus appears to represent a class effect of mTOR inhibitors.<\/jats:p>","DOI":"10.1159\/000104818","type":"journal-article","created":{"date-parts":[[2007,6,28]],"date-time":"2007-06-28T07:30:46Z","timestamp":1183015846000},"page":"253-259","source":"Crossref","is-referenced-by-count":99,"title":["Everolimus Retards Cyst Growth and Preserves Kidney Function in a Rodent Model for Polycystic Kidney Disease"],"prefix":"10.1159","volume":"30","author":[{"given":"Ming","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia R.","family":"Wahl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michel","family":"Le Hir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"W\u00e4ckerle-Men","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rudolf P.","family":"W\u00fcthrich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas L.","family":"Serra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2007,6,27]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097%2F01.pap.0000201831.77472.d3"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMra022161"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1101%2Fgad.1212704"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.0509694103"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1681%2FASN.2004080660"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfi181"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.0601352103"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2F0024-3205%2895%2902233-3"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097%2F00007890-199707150-00008"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1517%2F14656566.7.10.1347"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1681%2FASN.2005060601"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00418-005-0023-y"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1152%2Fajprenal.00286.2005"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097%2F01.TP.0000162436.17526.0F"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1097%2F00007890-199707150-00007"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1159%2F000020648"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1097%2F01.ASN.0000102469.32182.8C"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097%2F01.ASN.0000139932.00971.E4"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.bjp.0706259"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-6143.2005.01120.x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1523-1755.2005.00350.x"}],"container-title":["Kidney and Blood Pressure Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/104818","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/104818","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T22:58:41Z","timestamp":1745449121000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000104818"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":21,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2007,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000104818","archive":["Portico"],"relation":{},"ISSN":["1420-4096","1423-0143"],"issn-type":[{"value":"1420-4096","type":"print"},{"value":"1423-0143","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007]]}}}