{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,11]],"date-time":"2026-01-11T17:44:46Z","timestamp":1768153486130,"version":"3.49.0"},"reference-count":18,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology"],"published-print":{"date-parts":[[2007]]},"abstract":"The contribution of \u03b2-adrenoceptor subtypes to the catecholamine-mediated relaxations in gastric fundus from control and streptozotocin (STZ)-induced diabetic rats were investigated. Isolated organ bath studies and molecular techniques were used to characterize the \u03b2-adrenoceptor subtypes mediating relaxation of rat gastric fundus. Isoprenaline-mediated relaxation was not significantly changed by nadolol (\u03b2<sub>1<\/sub>-\/\u03b2<sub>2<\/sub>-adrenoceptor antagonist; 1 \u00b5mol\/l) but only shifted to the right by SR59230A (3-(2-ethylphenoxy)-1-[[(1S)-1,2,3,4-tetrahydronaphth-1-yl]amino]-(2S)-2-propanol oxalate salt, 0.1\u20131 \u00b5mol\/l), a selective \u03b2<sub>3<\/sub>-adrenoceptor antagonist, in a competitive manner. Relaxant responses to noradrenaline were antagonized in a concentration-dependent manner by SR59230A (0.1\u20131 \u00b5mol\/l), but not by metoprolol (selective \u03b2<sub>1<\/sub>-adrenoceptor antagonist; 0.1\u20131 \u00b5mol\/l) and ICI-118551 (1-[2,3-(dihydro-7-methyl-1Hinden- 4-yl)oxy]-3-[(1-methylethyl)amino]-2-butanol hydrochloride, selective \u03b2<sub>2<\/sub>-adrenoceptor antagonist; 0.1\u20131 \u00b5mol\/l). SR59230A (1 \u00b5mol\/l) also caused a significant rightward shift in fenoterol-induced relaxation while ICI-118551 (1 \u00b5mol\/l) did not have any effect. Selective \u03b2<sub>3<\/sub>-adrenoceptor agonist, BRL37344 ([4-[2-[[2-(3-chlorophenyl)-2-hydroxyethyl]amino]propyl]phenoxy]acetic acid), caused biphasic relaxation which was not affected by nadolol (1 \u00b5mol\/l). SR59230A (1 \u00b5mol\/l) abolished only the first phase of BRL37344 response. \u03b2<sub>1<\/sub>-, \u03b2<sub>2<\/sub>- and \u03b2<sub>3<\/sub>-adrenoceptor mRNA expressions have been detected in a similar intensity in gastric fundus from control rats. Experimental diabetes caused a significant decrease in E<sub>max<\/sub> and pD<sub>2<\/sub> values of isoprenaline and noradrenaline. Diabetes also reduced E<sub>max<\/sub> but not pD<sub>2<\/sub> value of the first component of BRL37344-induced relaxation response. The band intensity of mRNA transcript of \u03b2<sub>3<\/sub>-adrenoceptor was reduced in diabetics while no alteration has been found for \u03b2<sub>1<\/sub>- and \u03b2<sub>2<\/sub>-adrenoceptor mRNA transcripts between groups. These results show that functional \u03b2-adrenoceptor subtype involved in catecholamine-mediated relaxations is \u03b2<sub>3<\/sub>-adrenoceptor, and its function and mRNA expression are decreased in diabetes.<\/jats:p>","DOI":"10.1159\/000104876","type":"journal-article","created":{"date-parts":[[2007,7,6]],"date-time":"2007-07-06T12:58:57Z","timestamp":1183726737000},"page":"227-238","source":"Crossref","is-referenced-by-count":8,"title":["Role of Beta-3-Adrenoceptor in Catecholamine-Induced Relaxations in Gastric Fundus from Control and Diabetic Rats"],"prefix":"10.1159","volume":"80","author":[{"given":"Isil","family":"Ozakca","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ebru","family":"Arioglu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sahika","family":"Guner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V. Melih","family":"Altan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. Tanju","family":"Ozcelikay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2007,7,6]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1472-8206.1995.tb00270.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.bjp.0702797"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI118823"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038%2F214597a0"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002%2Fmed.2610130604"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159%2F000028332"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.bjp.0702605"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0014-2999%2899%2900355-6"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2680.1999.00121.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1023%2FA%3A1026647417465"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2F0024-3205%2891%2990505-6"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159%2F000138263"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2F0014-2999%2884%2990007-4"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159%2F000056078"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1540%2Fjsmr.37.105"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00210-002-0602-6"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1139%2Fcjpp-79-12-985"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1007%2FBF02208577"}],"container-title":["Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/104876","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/104876","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:59:06Z","timestamp":1745463546000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000104876"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":18,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2007,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000104876","archive":["Portico"],"relation":{},"ISSN":["0031-7012","1423-0313"],"issn-type":[{"value":"0031-7012","type":"print"},{"value":"1423-0313","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007]]}}}