{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T21:30:18Z","timestamp":1789421418469,"version":"build-2803163510"},"reference-count":15,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Acta Haematol"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>We examined the clinical usefulness of 3 parameters of routine laboratory tests [platelet-large cell ratio (P-LCR), lactate dehydrogenase (LDH) and C-reactive protein (CRP)] in 84 patients with thrombocytosis-related diseases (reactive thrombocytosis, chronic myeloid leukemia, essential thrombocythemia and polycythemia vera). These thrombocytosis-related diseases were characterized using the 3 parameters P-LCR, LDH and CRP as follows: high P-LCR and high LDH in chronic myeloid leukemia; high CRP in reactive thrombocytosis; slightly high P-LCR and high LDH in essential thrombocythemia and polycythemia vera. For essential thrombocythemia and polycythemia vera, levels of P-LCR and CRP were nearly identical, but the LDH level in essential thrombocythemia was significantly higher than in polycythemia vera. These characteristics of P-LCR, LDH and CRP may be useful for simple and very rough differentiation of the thrombocytosis-related disease mentioned above.<\/jats:p>","DOI":"10.1159\/000105167","type":"journal-article","created":{"date-parts":[[2007,7,11]],"date-time":"2007-07-11T11:21:40Z","timestamp":1184152900000},"page":"84-87","source":"Crossref","is-referenced-by-count":11,"title":["Characteristic Changes in Platelet-Large Cell Ratio, Lactate Dehydrogenase and C-Reactive Protein in Thrombocytosis-Related Diseases"],"prefix":"10.1159","volume":"118","author":[{"given":"Osamu","family":"Kabutomori","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzuru","family":"Kanakura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinori","family":"Iwatani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2007,7,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood.V98.9.2720"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1136%2Fjcp.39.2.129"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0145-2126%2801%2900017-0"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002%2Fajh.10114"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002%2Fajh.2830160208"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-0609.1996.tb00717.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-0609.1990.tb00349.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2141.1986.tb07576.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1002%2F1097-0142%2819880615%2961%3A12%3C2487%3A%3AAID-CNCR2820611217%3E3.0.CO%3B2-T"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2F0167-4889%2891%2990207-E"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007%2Fs002770050446"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2141.2005.05674.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.humpath.2006.05.006"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2006-01-013540"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.2353%2Fjmoldx.2006.050128"}],"container-title":["Acta Haematologica"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/105167","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/105167","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:01:59Z","timestamp":1745463719000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000105167"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":15,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2007,9,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000105167","archive":["Portico"],"relation":{},"ISSN":["0001-5792","1421-9662"],"issn-type":[{"value":"0001-5792","type":"print"},{"value":"1421-9662","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007]]}}}