{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,3]],"date-time":"2025-10-03T09:00:52Z","timestamp":1759482052265,"version":"3.40.4"},"reference-count":10,"publisher":"S. Karger AG","issue":"3-4","license":[{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2006,1,1]],"date-time":"2006-01-01T00:00:00Z","timestamp":1136073600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Oncology"],"published-print":{"date-parts":[[2006]]},"abstract":"<jats:p>&lt;i&gt;Objective:&lt;\/i&gt; There is little information on Herpes zoster infection in breast cancer patients as a complication during adjuvant chemotherapy. The aim of this study is to evaluate the incidence of Herpes zoster and simplex infections in this patients setting. &lt;i&gt;Methods:&lt;\/i&gt; We analyzed 623 early-stage breast cancer patients in our Institute over a period of 7 years (1998\u20132005). Four-hundred and sixty-onepatients were treated with anthracycline-based chemotherapy, 116 with CMF and 46 with taxane-containing regimens. &lt;i&gt;Results:&lt;\/i&gt; Twelve (1.9%) developed herpes zoster; 9 patients, receiving anthracycline-based chemotherapy, two taxane-containing regimens, and one CMF regimen. Herpes zoster infection required treatment delay in 6 patients. Adjuvant chemotherapy was delayed for 1 week in 2 patients, while in 4 patients with more severe symptoms chemotherapy was delayed for 2 weeks. One patient, despite i.v. acyclovir, had severe postherpetic motor neuropathy with a permanent ambulation impairment, and chemotherapy was stopped. In our study, herpes zoster occurred in 55\/1,000 cases\/year. The reported incidence in the general population varies between 2.2 and 4.1 per 1,000 patients\/year; therefore, the risk of developing herpes zoster in these patients may be 13- to 25-fold higher compared to the incidence in the general population. In addition, 13 of 623 patients developed herpes simplex. &lt;i&gt;Conclusion:&lt;\/i&gt; Our findings suggest that adjuvant chemotherapy can facilitate reactivation of herpes infection.<\/jats:p>","DOI":"10.1159\/000106065","type":"journal-article","created":{"date-parts":[[2007,7,23]],"date-time":"2007-07-23T14:23:17Z","timestamp":1185200597000},"page":"164-167","source":"Crossref","is-referenced-by-count":17,"title":["Herpes Infections in Breast Cancer Patients Treated with Adjuvant Chemotherapy"],"prefix":"10.1159","volume":"71","author":[{"given":"Giovanna","family":"Masci","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Massimo","family":"Magagnoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Gullo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuela","family":"Morenghi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabella","family":"Garassino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matteo","family":"Simonelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armando","family":"Santoro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2007,7,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2F0002-9343%2878%2990791-X"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002%2F1097-0142%2819850801%2956%3A3%3C642%3A%3AAID-CNCR2820560334%3E3.0.CO%3B2-N"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2F0002-9343%2882%2990760-4"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS0163-4453%2899%2990079-8"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1001%2Farchinte.155.15.1605"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1093%2Ffampra%2F19.5.471"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1525-1497.2005.0150.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.bmt.1703274"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2FS1083-8791%2800%2970051-6"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.bmt.1701594"}],"container-title":["Oncology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/106065","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/106065","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:34:49Z","timestamp":1745462089000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000106065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006]]},"references-count":10,"journal-issue":{"issue":"3-4","published-online":{"date-parts":[[2007,8,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000106065","archive":["Portico"],"relation":{},"ISSN":["0030-2414","1423-0232"],"issn-type":[{"type":"print","value":"0030-2414"},{"type":"electronic","value":"1423-0232"}],"subject":[],"published":{"date-parts":[[2006]]}}}