{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:30:35Z","timestamp":1790857835732,"version":"4.1.0"},"reference-count":19,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>Asthma is an inflammatory lung disease, in which CD1d-restricted natural killer T (NKT) cells play an importantpathogenic role. Also, recent reports indicated that a cytokine, thymic stromal lymphopoietin (TSLP), is essential for the development of antigen-induced asthma. Here we examined the relationship between NKT cells and TSLP in a mouse model of asthma. NKT cells express TSLP receptor as well as IL-7 receptor \u03b1-chain. TSLP acts on NKT cells to preferentially increase their IL-13 production but not IFN-\u03b3 and IL-4. In an allergen-induced asthma model, the development of airway hyperreactivity, a cardinal feature of asthma, was increased in TSLP transgenic mice, whereas this effect was not observed in TSLP transgenic mice lacking NKT cells. Interestingly, in the NKT cell-lacking TSLP transgenic mice, pulmonary eosinophilia and increase in IgE did not improve. Pulmonary lymphocytes from the NKT cell-lacking TSLP transgenic mice produced much less IL-13 upon CD3 stimulation than those from NKT cell-competent TSLP transgenic mice. These resultssuggest that, in allergen-induced asthma, TSLP acts on NKT cells to enhance airway hyperreactivity by upregulating their IL-13 production, whereas eosinophilia and IgE production are not influenced.<\/jats:p>","DOI":"10.1159\/000106319","type":"journal-article","created":{"date-parts":[[2007,7,23]],"date-time":"2007-07-23T14:23:17Z","timestamp":1185200597000},"page":"305-314","source":"Crossref","is-referenced-by-count":87,"title":["Differential Role of Thymic Stromal Lymphopoietin in the Induction of Airway Hyperreactivity and Th2 Immune Response in Antigen-Induced Asthma with Respect to Natural Killer T Cell Function"],"prefix":"10.1159","volume":"144","author":[{"given":"Yuko","family":"Nagata","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajime","family":"Kamijuku","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masaru","family":"Taniguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven","family":"Ziegler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken-ichiro","family":"Seino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2007,7,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038%2Fni0802-715"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI8124"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM198902023200502"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1146%2Fannurev.immunol.21.120601.141057"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1146%2Fannurev.immunol.22.012703.104608"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038%2Fnm851"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.0510282103"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa053614"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1038%2Fni1247"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038%2Fnrm910"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1084%2Fjem.20050199"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.278.5343.1623"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1038%2F76923"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1084%2Fjem.20031975"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2FS0167-5699%2800%2901735-7"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2FS1525-0016%2802%2900050-3"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.immuni.2006.03.019"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1084%2Fjem.20030630"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.immuni.2006.04.009"}],"container-title":["International Archives of Allergy and Immunology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/106319","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/106319","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:37:37Z","timestamp":1745462257000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000106319"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":19,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2007,11,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000106319","archive":["Portico"],"relation":{},"ISSN":["1018-2438","1423-0097"],"issn-type":[{"value":"1018-2438","type":"print"},{"value":"1423-0097","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007]]}}}