{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T18:16:21Z","timestamp":1757700981086,"version":"3.40.4"},"reference-count":20,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Fetal Diagn Ther"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>&lt;i&gt;Objective:&lt;\/i&gt; Isolated fetal heart block (HB), a condition associated with fetal hydrops, carries a high mortality rate and may result in neurodevelopmental sequelae. To the best of our knowledge, no data exist regarding the long-term outcome of such hydropic fetuses. We reviewed our experience with this condition to determine the neurodevelopmental outcome of prenatally diagnosed cases with isolated HB complicated by hydrops fetalis. &lt;i&gt;Methods:&lt;\/i&gt; Neurodevelopmental assessment of 5 children presented prenatally with isolated HB associated with hydrops fetalis. &lt;i&gt;Results:&lt;\/i&gt; During the last 18 years, 10 cases were detected prenatally with isolated HB and hydrops fetalis. 3 of the 10 fetuses died in utero, and 2 died postnatally, due to a dilated cardiomyopathy, at the age of 9 months and 4 years, respectively. Neurodevelopmental studies done on the 5 remaining children were normal. &lt;i&gt;Conclusion:&lt;\/i&gt; Long-term neurodevelopmental assessments of 5 surviving cases presented prenatally with isolated HB and hydrops fetalis are reassuring.<\/jats:p>","DOI":"10.1159\/000106355","type":"journal-article","created":{"date-parts":[[2007,7,25]],"date-time":"2007-07-25T09:36:15Z","timestamp":1185356175000},"page":"457-461","source":"Crossref","is-referenced-by-count":9,"title":["Neurological Outcome in Isolated Congenital Heart Block and Hydrops Fetalis"],"prefix":"10.1159","volume":"22","author":[{"given":"Johannes M.P.J.","family":"Breur","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rob H.J.M.","family":"Gooskens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Livia","family":"Kapusta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Philip","family":"Stoutenbeek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerard H.A.","family":"Visser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul","family":"van den Berg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik J.","family":"Meijboom","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2007,7,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9149%2883%2980042-3"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM198501103120206"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM198609113151103"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM198307283090403"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS0735-1097%2898%2900161-2"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1136%2Fhrt.60.6.512"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2FS0735-1097%2801%2901697-7"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1542%2Fpeds.106.1.86"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2FS0735-1097%2810%2980148-2"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1136%2Fhrt.75.2.190"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1002%2Fart.1780360309"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002%2Fart.1780251101"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1469-0705.1999.13010043.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159%2F000243754"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2F0887-8994%2894%2990084-1"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1097%2F00006254-199104000-00015"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2FS0735-1097%2800%2901209-2"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1136%2Fard.2005.049866"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1001%2Farchpedi.157.4.397"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1161%2F01.CIR.0000023900.58293.FE"}],"container-title":["Fetal Diagnosis and Therapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/106355","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/106355","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:37:52Z","timestamp":1745462272000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000106355"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":20,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2007,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000106355","archive":["Portico"],"relation":{},"ISSN":["1015-3837","1421-9964"],"issn-type":[{"type":"print","value":"1015-3837"},{"type":"electronic","value":"1421-9964"}],"subject":[],"published":{"date-parts":[[2007]]}}}