{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T04:24:06Z","timestamp":1778559846209,"version":"3.51.4"},"reference-count":23,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2007,7,25]],"date-time":"2007-07-25T00:00:00Z","timestamp":1185321600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,7,25]],"date-time":"2007-07-25T00:00:00Z","timestamp":1185321600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2008]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Spinal cord injury has been reported after perinatal asphyxia in full-term neonates. &lt;i&gt;Objectives:&lt;\/i&gt; To examine the role of excessive nitric oxide production in perinatal spinal cord injury. &lt;i&gt;Subjects and Methods:&lt;\/i&gt; Tissue samples of 18 full-term neonates who died of hypoxic-ischemic encephalopathy were analyzed for the presence of nitrotyrosine (NT). &lt;i&gt;Results:&lt;\/i&gt; NT was demonstrated in 5 of these 18 neonates. In addition, activated caspase 3, a marker of apoptosis, and CD68, as a marker of inflammation, could be demonstrated in some infants. &lt;i&gt;Conclusions:&lt;\/i&gt; excessive nitric oxide production and subsequent NT formation is seen in spinal cord tissue after severe perinatal asphyxia. This finding may be relevant for the development of neuroprotective strategies.<\/jats:p>","DOI":"10.1159\/000106432","type":"journal-article","created":{"date-parts":[[2007,7,27]],"date-time":"2007-07-27T14:15:44Z","timestamp":1185545744000},"page":"1-6","source":"Crossref","is-referenced-by-count":22,"title":["Nitrotyrosine in Human Neonatal Spinal Cord after Perinatal Asphyxia"],"prefix":"10.1159","volume":"93","author":[{"given":"Floris","family":"Groenendaal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Johannes","family":"Vles","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harry","family":"Lammers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"De Vente","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diane","family":"Smit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter G.J.","family":"Nikkels","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2007,7,25]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0095-5108%2802%2900059-3"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159%2F000069044"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2FS0387-7604%2803%2900166-9"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMra041996"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1136%2Fadc.2005.092114"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1021%2Ftx00030a017"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1385%2FMN%3A27%3A3%3A325"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.410250213"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMcps050929"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2803%2912658-X"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00401-005-1077-6"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9610%2898%2900133-0"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1203%2F01.PDR.0000075220.17631.F1"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1203%2F00006450-199806000-00004"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1006%2Fjsre.1999.5754"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2FS0022-510X%2898%2900224-X"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.cr.7290306"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-4547%2819990115%2955%3A2%3C158%3A%3AAID-JNR3%3E3.0.CO%3B2-1"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2FS0006-8993%2899%2902434-8"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2FS0306-4522%2802%2900134-3"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.222550499"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016%2FS0003-4975%2800%2901354-0"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1097%2F00008506-200101000-00002"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/106432","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/106432","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:38:26Z","timestamp":1745462306000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000106432"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7,25]]},"references-count":23,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2007,12,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000106432","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"value":"1661-7800","type":"print"},{"value":"1661-7819","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,7,25]]}}}