{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T13:57:41Z","timestamp":1761919061117,"version":"3.40.4"},"reference-count":33,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytogenet Genome Res"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>The dic(7;9)(p11\u223c13;p11\u223c13) is a recurrent chromosomal abnormality in acute lymphoblastic leukemia (ALL), mainly of B-lineage. Although more than 20 dic(7;9)-positive ALLs have been reported to date, the molecular genetic consequences of this aberration are unknown. We performed tiling resolution (32K) genome-wide array-based comparative genomic hybridization (array CGH) analysis of three cases with dic(7;9) in order to characterize the breakpoints on 7p and 9p. The analysis showed a clustering of breakpoints within 9p13.1 in all three cases and within 7p11.2 in two cases; the array CGH revealed two different breakpoints \u2013 7p12.1 and 7p14.1 \u2013 in the remaining case. Based on these findings the abnormality should hence be designated dic(7;9)(p11.2\u223c12.1;p13.1). Locus-specific fluorescence in situhybridization analysis of one of the cases narrowed down the 7p11.2 breakpoint to a &lt;500-kb segment in this sub-band, a region containing three known genes. Unfortunately, lack of material precluded further molecular genetic studies, and it thus remains unknown whether the pathogenetically important outcome of the dic(7;9) is formation of a chimeric gene or loss of 7p and\/or 9p material.<\/jats:p>","DOI":"10.1159\/000106436","type":"journal-article","created":{"date-parts":[[2007,10,2]],"date-time":"2007-10-02T08:53:46Z","timestamp":1191315226000},"page":"13-18","source":"Crossref","is-referenced-by-count":12,"title":["Tiling resolution array CGH of dic(7;9)(p11\u223c13;p11\u223c13) in B-cell precursor acute lymphoblastic leukemia reveals clustered breakpoints at 7p11.2\u223c12.1 and 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