{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T18:59:46Z","timestamp":1779217186821,"version":"3.51.4"},"reference-count":23,"publisher":"S. Karger AG","issue":"2-3","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestion"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Previous studies suggested that Chinese have a milder spectrum of gastro-oesophageal reflux disease and a lower dose of proton pump inhibitors (PPI) is sufficient for the control of symptoms as compared with the Western population. &lt;i&gt;Aims:&lt;\/i&gt; To determine if 8 weeks of esomeprazole 20 mg daily would be adequate for both symptom resolution and oesophagitis healing in Chinese patients and the predictive factors for the response. &lt;i&gt;Methods:&lt;\/i&gt; 66 patients with oesophagitis were included. Oesophagitis severity was graded by Los Angeles (LA) classification. 61 patients underwent 24-hour ambulatory pH study at baseline. All were given esomeprazole 20 mg daily for 8 weeks. Symptom response and healing of oesophagitis was assessed at the end of the treatment period. &lt;i&gt;Results:&lt;\/i&gt; 75.8% of the patients had complete reflux symptom resolution but only 48% had complete healing of the oesophagitis at endoscopy after 8 weeks of treatment. LA classification grading at baseline endoscopy (p &lt; 0.0001) and total number acid reflux episodes on 24-hour pH monitoring prior to treatment (p = 0.007) were both good predictors of oesophagitis healing but not for symptom resolution. &lt;i&gt;Conclusions:&lt;\/i&gt; Our results suggested that 8 weeks of lower dose PPI is not sufficient for oesophagitis healing. Symptom resolution with PPI does not predict oesophagitis healing in Chinese.<\/jats:p>","DOI":"10.1159\/000106453","type":"journal-article","created":{"date-parts":[[2007,7,31]],"date-time":"2007-07-31T10:06:17Z","timestamp":1185876377000},"page":"128-134","source":"Crossref","is-referenced-by-count":10,"title":["Symptom Resolution Does Not Predict Healing of Erosive Oesophagitis in Chinese"],"prefix":"10.1159","volume":"75","author":[{"given":"Ting Kin","family":"Cheung","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wai Man","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nina Y.H.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chi Kuen","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James","family":"Fung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Man Fung","family":"Yuen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annie O.O.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teresa S.M.","family":"Tong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Benjamin C.Y.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2007,7,31]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0016-5085%2897%2970025-8"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.cgh.2005.10.011"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1440-1746.2006.04254.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2036.2002.01373.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1136%2Fgut.44.4.449"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1440-1746.2000.02148.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1001%2Farchinte.159.7.649"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2036.2004.01846.x"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1136%2Fgut.45.2.172"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2036.2003.01576.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1440-1746.2004.03419.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1136%2Fgut.31.5.509"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1572-0241.2000.03254.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097%2F00004836-200404000-00007"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2036.17.s1.6.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2036.2000.00856.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1136%2Fgut.21.4.324"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1023%2FB%3ADDAS.0000007857.15694.15"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1097%2F01.smj.0000224274.05081.b5"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2FS0016-5107%2899%2970313-5"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1007%2FBF01296431"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1097%2F00004836-200605000-00007"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1440-1746.2002.02783.x"}],"container-title":["Digestion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/106453","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/106453","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:38:37Z","timestamp":1745462317000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000106453"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":23,"journal-issue":{"issue":"2-3","published-online":{"date-parts":[[2007,8,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000106453","archive":["Portico"],"relation":{},"ISSN":["0012-2823","1421-9867"],"issn-type":[{"value":"0012-2823","type":"print"},{"value":"1421-9867","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007]]}}}