{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T03:57:15Z","timestamp":1778731035937,"version":"3.51.4"},"reference-count":17,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2007,7,31]],"date-time":"2007-07-31T00:00:00Z","timestamp":1185840000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,7,31]],"date-time":"2007-07-31T00:00:00Z","timestamp":1185840000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Gynecol Obstet Invest"],"published-print":{"date-parts":[[2008]]},"abstract":"<jats:p>&lt;i&gt;Objective:&lt;\/i&gt; To evaluate the placental expression of transforming growth factor-\u03b23 (TGF-\u03b23) in patients with HELLP syndrome and pre-eclampsia compared to controls, and its correlation to Doppler velocimetry analysis of the utero-placental blood flow. &lt;i&gt;Study Design:&lt;\/i&gt; Real-time PCR analysis was performed, after cesarean section, in placental samples from 10 women affected by HELLP syndrome, 10 women with pre-eclampsia and 10 controls. Pulsatility indices on Doppler waveform analysis from uterine and umbilical arteries were measured. &lt;i&gt;Results:&lt;\/i&gt; The mean TGF-\u03b23 expression was significantly higher in patients with HELLP syndrome compared with the control group (p &lt; 0.001), and no difference was observed in the pre-eclampsia group. TGF-\u03b23 expression correlated positively with umbilical PI (p &lt; 0.001). &lt;i&gt;Conclusions:&lt;\/i&gt; TGF-\u03b23 may play a key role as regulator of a variety of cellular events occurring during HELLP syndrome, high local expression of this growth factor may be responsible for remodeling of the placental structure, which results in the dysfunction of maternal-fetal circulation.<\/jats:p>","DOI":"10.1159\/000106497","type":"journal-article","created":{"date-parts":[[2016,5,24]],"date-time":"2016-05-24T02:57:12Z","timestamp":1464058632000},"page":"1-5","source":"Crossref","is-referenced-by-count":7,"title":["Placental Overexpression of Transforming Growth Factor-\u03b23 in the HELLP Syndrome"],"prefix":"10.1159","volume":"65","author":[{"given":"M.","family":"Emanuelli","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.R.","family":"Giannubilo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Landi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Sartini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Pierella","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Corradetti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.L.","family":"Tranquilli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2007,7,31]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1002%2Fpath.1700930218"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0143-4004%2883%2980043-5"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI119388"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS0146-0005%2899%2980057-3"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2F0140-6736%2893%2990889-O"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9378%2899%2970239-5"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2FS0165-0378%2803%2900044-5"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.86.6.2505"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1515%2FJPM.2003.021"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2FS1359-6101%2896%2900048-2"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI6380"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3109%2F10641950109152635"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1469-0705.1993.03010018.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2FS0002-9378%2898%2970160-7"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1053%2Fplac.2001.0778"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1083%2Fjcb.124.1.171"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2362.2000.00647.x"}],"container-title":["Gynecologic and Obstetric Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/106497","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/106497","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:39:01Z","timestamp":1745462341000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000106497"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7,31]]},"references-count":17,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2008,1,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000106497","archive":["Portico"],"relation":{},"ISSN":["0378-7346","1423-002X"],"issn-type":[{"value":"0378-7346","type":"print"},{"value":"1423-002X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,7,31]]}}}