{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:09:37Z","timestamp":1791155377866,"version":"4.1.0"},"reference-count":6,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Thalidomide has antiangiogenic and immunomodulatory properties and has recently been used in the management of human malignancies. Several studies have suggested its interest for treating AIDS-related Kaposi\u2019s sarcoma. &lt;i&gt;Objectives:&lt;\/i&gt; This study aimed to assess the efficacy and toxicity of thalidomide, an antiangiogenic agent, for the treatment of non-HIV-related Kaposi\u2019s sarcoma. &lt;i&gt;Methods:&lt;\/i&gt; Eleven patients were included in this retrospective study conducted in the Department of Dermatology of Saint Louis, Paris, between 2000 and 2003. Among them, 2 were immunosuppressed (1 renal transplant recipient and 1 patient with microscopic polyangiitis treated by oral steroids) with stable immunosuppressive regimens during the past 6 months. The median daily thalidomide dosage was 100 mg and the median duration of drug treatment was 16 weeks. &lt;i&gt;Results:&lt;\/i&gt; Three patients achieved a partial response and 4 had a stable disease. Although no grade 3 or 4 was observed, 3 (27%) out of 11 patients prematurely discontinued thalidomide because of grade 1 sensory neuropathy (paresthesia) and vertigo. &lt;i&gt;Conclusions:&lt;\/i&gt; Our results show a true although modest interest of thalidomide in non-HIV-related Kaposi\u2019s sarcoma and prompt us to evaluate less toxic thalidomide analogues for this indication.<\/jats:p>","DOI":"10.1159\/000106576","type":"journal-article","created":{"date-parts":[[2007,9,10]],"date-time":"2007-09-10T08:41:19Z","timestamp":1189413679000},"page":"202-205","source":"Crossref","is-referenced-by-count":19,"title":["A Retrospective Analysis of Thalidomide Therapy in Non-HIV-Related Kaposi\u2019s Sarcoma"],"prefix":"10.1159","volume":"215","author":[{"given":"Lilia","family":"Ben M\u2019barek","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence","family":"Fardet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amel","family":"Mebazaa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Thervet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Israel","family":"Biet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"K\u00e9rob","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrice","family":"Morel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9leste","family":"Lebbe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2007,9,12]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1200%2FJCO.2004.10.127"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1159%2F000076491"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1159%2F000093856"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1080%2F07357900500358259"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159%2F000039743"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1258%2F0956462981921512"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/106576","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/106576","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:39:37Z","timestamp":1745462377000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000106576"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":6,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2007,9,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000106576","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007]]}}}