{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:21:46Z","timestamp":1761708106481,"version":"3.40.4"},"reference-count":32,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Psoriasis vulgaris requires lifelong treatment associated with considerable health cost. Studies showed that a combination of a steroid and a vitamin D&lt;sub&gt;3&lt;\/sub&gt; analogue is more effective than both compounds in monotherapy. &lt;i&gt;Objective:&lt;\/i&gt; To determine the cost-effectiveness of a fix calcipotriol\/betamethasone combination (Daivobet\u00ae\/Dovobet\u00ae\/Taclonex\u00ae) compared to a morning\/evening non-fix calcipotriol\/betamethasone combination in psoriasis treatment. &lt;i&gt;Methods:&lt;\/i&gt; A Markov model (discrete-time stochastic process based on transitions between health states) with 2 treatment arms (Daivobet\/Dovobet\/Taclonex vs. non-fix calcipotriol\/betamethasone) over a 48-week time period was developed. The effectiveness criterion was the number of days with clearance or marked improvement. Clinical and health resource utilisation data were derived from randomised studies. &lt;i&gt;Results:&lt;\/i&gt; Treatment with Daivobet\/Dovobet\/Taclonex showed a higher cost-effectiveness compared to the non-fix combination, even when assuming a maximum compliance for the twice daily non-fix combination and varying the effectiveness of Daivobet\/Dovobet\/Taclonex by 10%. &lt;i&gt;Conclusion:&lt;\/i&gt; Psoriasis treatment with a fix calcipotriol\/betamethasone combination is more cost-effective than a non-fix morning\/evening combination.<\/jats:p>","DOI":"10.1159\/000106791","type":"journal-article","created":{"date-parts":[[2007,9,10]],"date-time":"2007-09-10T08:41:19Z","timestamp":1189413679000},"page":"219-228","source":"Crossref","is-referenced-by-count":20,"title":["Cost-Effectiveness Model of Topical Treatment of Mild to Moderate Psoriasis Vulgaris in 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