{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T03:49:14Z","timestamp":1786765754419,"version":"build-2736575974"},"reference-count":16,"publisher":"S. Karger AG","issue":"2-3","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestion"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Pancreatitis is the most serious complication of endoscopic retrograde cholangiopancreatography (ERCP), occurring in 2\u201320% of the patients. Currently there is no information about the impact of preoperative pancreatitis on the surgical management of periampullary tumors. &lt;i&gt;Methods:&lt;\/i&gt; Ten patients with periampullary tumors and preoperative acute pancreatitis were retrospectively analyzed. Four patients who underwent pylorus-preserving pancreaticoduodenectomy (group A) and 6 patients who underwent total pancreatectomy (group B) were compared with a matching control group (age, gender, stage, tumor and operation type) of 30 patients without pancreatitis (group C) who underwent an operation during the same period. Parameters analyzed were C-reactive protein (CRP), leukocytes, aminotransferases, amylase, lipase, operative time, blood loss, hospital stay, morbidity, and mortality. &lt;i&gt;Results:&lt;\/i&gt; In the study group, 5 patients had pancreatic adenocarcinoma, 3 had distal bile duct cancers, and 2 had ampullary tumors. None of the patients had severe acute necrotizing pancreatitis that necessitated intervention prior to tumor resection. Preoperative median CRP levels in group B were 8.4- and 5.6-fold higher than those of groups A and C, respectively. In contrast, leukocytes, aminotransferases, amylase, and lipase levels were not significantly different. The presence of acute pancreatitis slightly prolonged the duration of the operation (+15 min), increased morbidity (60 vs. 33%) and lengthened median hospital stay (19.5 vs. 14.5 days) in groups A and B vs. group C. All patients with preoperative pancreatitis were managed without mortality. &lt;i&gt;Conclusion:&lt;\/i&gt; Preoperative pancreatitis is more commonly seen in patients with non-pancreatic periampullary tumors, and considerably influences surgical management. High preoperative CRP levels indicate a more severe form of pancreatic damage that may necessitate a total pancreatectomy.<\/jats:p>","DOI":"10.1159\/000106799","type":"journal-article","created":{"date-parts":[[2007,8,8]],"date-time":"2007-08-08T15:14:40Z","timestamp":1186586080000},"page":"165-171","source":"Crossref","is-referenced-by-count":11,"title":["Preoperative Acute Pancreatitis in Periampullary Tumors: Implications for Surgical Management"],"prefix":"10.1159","volume":"75","author":[{"given":"Mert","family":"Erkan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg","family":"Kleeff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolin","family":"Reiser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulf","family":"Hinz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Esposito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helmut","family":"Friess","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Markus W.","family":"B\u00fcchler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2007,8,7]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1097%2F01.sla.0000217673.04165.ea"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS1072-7515%2801%2900819-5"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1097%2F00000658-200207000-00005"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1572-0241.2006.00380.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS0016-5107%2891%2970740-2"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1067%2Fmge.2001.117550"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2FS0016-5107%2804%2902169-8"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097%2F00006676-199710000-00001"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097%2F01.sla.0000197334.58374.70"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.gie.2005.11.060"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159%2F000051445"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS1542-3565%2804%2900671-8"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2FS0016-5107%2804%2902013-9"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1002%2Fbjs.4881"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159%2F000094750"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1159%2F000091448"}],"container-title":["Digestion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/106799","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/106799","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:42:20Z","timestamp":1745462540000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000106799"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":16,"journal-issue":{"issue":"2-3","published-online":{"date-parts":[[2007,8,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000106799","archive":["Portico"],"relation":{},"ISSN":["0012-2823","1421-9867"],"issn-type":[{"value":"0012-2823","type":"print"},{"value":"1421-9867","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007]]}}}