{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:10:25Z","timestamp":1790730625933,"version":"4.1.0"},"reference-count":0,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[1995,1,1]],"date-time":"1995-01-01T00:00:00Z","timestamp":788918400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[1995,1,1]],"date-time":"1995-01-01T00:00:00Z","timestamp":788918400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord"],"published-print":{"date-parts":[[1995]]},"abstract":"<jats:p>The density of diffuse, primitive, classic and compact \u03b2-amyloid (\u03b2\/A4) deposits was estimated in the medial temporal lobe in elderly non-demented brains and in Alzheimer''s disease (AD). In the non-demented cases, \u03b2\/A4 deposits were absent in the hippocampus but in 8\/14 cases they were present in the adjacent cortical regions. Variation in \u03b2\/A4 deposition in the non-demented cases was large and overlapped with that of the AD cases. The ratio of mature to diffuse \u03b2\/A4 deposits was greater in the non-demented than in the AD cases. In both the non-demented cases and AD, the \u03b2\/A4 deposits were clustered with, in many tissues, a regular distribution of clusters along the cortex parallel to the pia. However, the mean cluster size of the deposits in the cortex was greater in AD than in the non-demented cases. These results suggest that the spread of \u03b2\/A4 pathology between the modular units of the cortex and into the hippocampus could be important factors in the development of AD.<\/jats:p>","DOI":"10.1159\/000106933","type":"journal-article","created":{"date-parts":[[2007,8,3]],"date-time":"2007-08-03T10:53:43Z","timestamp":1186138423000},"page":"121-125","source":"Crossref","is-referenced-by-count":7,"title":["Beta-Amyloid Deposition in the Medial Temporal Lobe in Elderly Non-Demented Brains and in Alzheimer\u2019s Disease"],"prefix":"10.1159","volume":"6","author":[{"given":"R.A.","family":"Armstrong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[1995,5,4]]},"container-title":["Dementia and Geriatric Cognitive Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/106933","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/106933","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:43:56Z","timestamp":1745462636000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000106933"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1995]]},"references-count":0,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2004,7,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000106933","archive":["Portico"],"relation":{},"ISSN":["1420-8008","1421-9824"],"issn-type":[{"value":"1420-8008","type":"print"},{"value":"1421-9824","type":"electronic"}],"subject":[],"published":{"date-parts":[[1995]]}}}