{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T15:26:03Z","timestamp":1775057163835,"version":"3.50.1"},"reference-count":11,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/karger.com\/pages\/terms-and-conditions"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Digestion"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>Background and Aim: Bangladesh is a developing country with a very high prevalence of Helicobacter pylori infection, which has been ascribed to overcrowding and poor sanitary conditions. It has generally been accepted that the re-infection rate is higher in countries with a high prevalence of H. pylori infection. Short-term follow-up studies support this assumption but no long-term studies are available to confirm or refute this assertion. The present study was aimed to define the long-term H. pylori re-infection rate (6 years after successful eradication) in duodenal ulcer patients. Methods: In a previous study, 90 patients were successfully eradicated for H. pylori and followed-up for 24 months. 17\/90 were found to be re-infected (18% re-infection rate per year in the first 12 months) [Gastroenterology 2001;792\u2013798]. The remaining 73 patients were targeted for long-term follow-up. 26\/73 were lost to follow-up; 6 symptomatic patients were tested H. pylori positive in the period between 24 and 60 months post-eradication. The remaining 41 patients were evaluated 72 months after successful eradication. The evaluation included clinical history taking, a 13C-urea breath test (UBT), and endoscopy. Results: Of the 41 H. pylori-eradicated patients analyzed after 72 months, 16 were H. pylori-positive. If the 6 patients, who were tested positive between 24 and 60 months, are added, the total re-infection cases amount to 22 subjects in the period between 24 and 72 months. Therefore, an overall annual re-infection rate 6 years after eradication of 5.02% can be calculated. Six of the 23 symptomatic patients had duodenal ulcer relapse, 5\/6 were H. pylori re-infected and one was H. pylori-negative at 72 months post-treatment. Conclusion: The long-term annual H. pylori re-infection rate in Bangladeshi adults is markedly higher than in Western countries but lower than anticipated. In this study, duodenal ulcer relapse is clearly related to H. pylori re-infection.<\/jats:p>","DOI":"10.1159\/000107046","type":"journal-article","created":{"date-parts":[[2007,8,15]],"date-time":"2007-08-15T14:58:41Z","timestamp":1187189921000},"page":"173-176","source":"Crossref","is-referenced-by-count":17,"title":["Long-Term Re-Infection Rate after Helicobacter pylori Eradication in Bangladeshi Adults"],"prefix":"10.1159","volume":"75","author":[{"given":"Mian Mashhud","family":"Ahmad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dewan Saifuddin","family":"Ahmed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.H.M.","family":"Rowshon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swapan Chandra","family":"Dhar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Motiur","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahmud","family":"Hasan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christoph","family":"Beglinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Niklaus","family":"Gyr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.K. Azad","family":"Khan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2007,8,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199110173251603"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007%2FBF02220458"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2F0140-6736%2893%2991172-I"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3109%2F00365529209000088"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1053%2Fgast.2001.28018"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.3109%2F00365529509090275"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1086%2F513779"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0016-5085%2898%2970475-5"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1097%2F00042737-199612000-00004"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2036.2005.02408.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1590%2FS0100-879X2001000600008"}],"container-title":["Digestion"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/karger.com\/dig\/article-pdf\/75\/4\/173\/4033163\/000107046.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/karger.com\/dig\/article-pdf\/75\/4\/173\/4033163\/000107046.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:45:14Z","timestamp":1745462714000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000107046"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":11,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2007,12,1]]},"published-print":{"date-parts":[[2007,4,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000107046","archive":["Portico"],"relation":{},"ISSN":["0012-2823","1421-9867"],"issn-type":[{"value":"0012-2823","type":"print"},{"value":"1421-9867","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007]]}}}