{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T12:50:23Z","timestamp":1784119823208,"version":"3.55.0"},"reference-count":15,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroendocrinology"],"published-print":{"date-parts":[[2007]]},"abstract":"<i>Background\/Aims:<\/i> Mid-gut carcinoids (MGC) are the most common of the gastrointestinal carcinoid tumours. There is a lack of reliable prognostic indicators for MGC. Cox-2 and Bcl-2 were evaluated as prognostic biomarkers in a cohort of well-characterised non-appendiceal MGC. <i>Methods:<\/i> Tissue from the primary MGC tumours of 37 patients was subjected to immunohistochemical detection of Cox-2 and Bcl-2. In 9 cases, tissue from secondary lesions was also examined. The study assessed whether tumour-associated Cox-2 and Bcl-2 expression were related to patient survival. <i>Results:<\/i> Cox-2 expression was demonstrated in 30\/36 primary tumours. When all tumours were analysed, Cox regression analysis indicated a trend towards worsening survival with increasing Cox-2 histoscore (intensity \u00d7 proportion; hazard ratio 1.53, 95% CI 0.93, 2.52; p = 0.09). Analysis of Cox-2-positive tumours revealed a highly significant association between increasing histoscore and decreased survival (hazard ratio 3.03, 95% CI 1.33, 6.91; p = 0.008). Tumour-associated Bcl-2 expression had no effect on patient survival (hazard ratio 1.12, 95% CI 0.42, 2.99; p = 0.82). There was no significant association between Cox-2 and Bcl-2 expression (\u03c7<sup>2<\/sup> p = 0.16), or Cox-2 histoscore and Bcl-2 expression (MWU p = 0.59). Analysis of the Cox-2 histoscores of primary tumours and their corresponding secondary lesions revealed a statistically significant trend towards increasing histoscore in the latter (Wilcoxon p = 0.04). <i>Conclusions:<\/i> This study has provided evidence that Cox-2 expression in primary MGC may be associated with a more negative prognostic outlook.<\/jats:p>","DOI":"10.1159\/000107555","type":"journal-article","created":{"date-parts":[[2007,8,17]],"date-time":"2007-08-17T09:30:12Z","timestamp":1187343012000},"page":"104-111","source":"Crossref","is-referenced-by-count":14,"title":["An Evaluation of Cyclooxygenase-2 as a Prognostic Biomarker in Mid-Gut Carcinoid Tumours"],"prefix":"10.1159","volume":"86","author":[{"given":"Ian","family":"Cadden","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian T.","family":"Johnston","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham","family":"Turner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"McCance","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joy","family":"Ardill","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann","family":"McGinty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2007,8,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2036.1999.00479.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1023%2FA%3A1008215730767"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1136%2Fgut.2006.092320"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1002%2Fjso.20188"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.282.13.1254"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2F0092-8674%2895%2990127-2"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1074%2Fjbc.M010787200"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0028-3908%2802%2900020-5"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1210%2Fjc.86.11.5615"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1093%2Fintimm%2F7.11.1817"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1136%2Fjcp.42.10.1043"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291097-0142%2819970315%2979%3A6%3C1086%3A%3AAID-CNCR5%3E3.0.CO%3B2-E"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002%2Fcncr.11105"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1053%2Fejso.2001.1229"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2FS0016-5085%2899%2970174-5"}],"container-title":["Neuroendocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/107555","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/107555","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:50:09Z","timestamp":1745463009000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000107555"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":15,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2007,9,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000107555","archive":["Portico"],"relation":{},"ISSN":["0028-3835","1423-0194"],"issn-type":[{"value":"0028-3835","type":"print"},{"value":"1423-0194","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007]]}}}