{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T16:58:37Z","timestamp":1785862717990,"version":"3.56.0"},"reference-count":26,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuroendocrinology"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>The pancreatic hormone amylin decreases food intake via activation of area postrema (AP) neurons. We investigated whether amylin\u2019s potency to reduce food intake and to induce c-Fos expression in the AP\/nucleus of the solitary tract region is affected by the feeding conditions and specifically by the macronutrient composition of the diet. Whereas a low dose of amylin (5 \u00b5g\/kg s.c.) induced very little c-Fos expression in ad libitum chow fed rats, it caused a strong c-Fos expression in 24-hour food-deprived rats and in rats that received a nutrient-deficient non-caloric mash (NCM; vanilla-flavoured cellulose) 24 h before injection. To reveal the contribution of single nutrients to the low c-Fos expression after chow feeding, amylin-induced c-Fos was analyzed after feeding NCM that was selectively supplemented with glucose, fat (lard), or protein (casein), matching the intake of these nutrients of chow-fed rats. While the rats fed NCM supplemented with glucose or fat displayed an equally strong amylin-induced activation as fasted rats or rats fed plain NCM, a significantly lower c-Fos expression was observed in rats fed a protein-supplemented NCM or a NCM containing all three nutrients. In line with this lower activation, the same dose of amylin failed to reduce food intake in NCM\/protein-fed rats, while amylin caused a reduction in feeding when animals received NCM, NCM\/glucose, or NCM\/fat. Interestingly, amylin effectively reduced food intake in ad libitum chow fed rats despite the low level of amylin-induced c-Fos expression in the AP under these conditions. We conclude that the anorectic potential of amylin may be attenuated by diet-derived proteins, whereas this effect appears to be overridden when the amount of carbohydrates\/fat is high relative to the protein content, such as, e.g., in standard chow.<\/jats:p>","DOI":"10.1159\/000107579","type":"journal-article","created":{"date-parts":[[2007,8,17]],"date-time":"2007-08-17T09:30:12Z","timestamp":1187343012000},"page":"124-135","source":"Crossref","is-referenced-by-count":28,"title":["Diet-Derived Nutrients Modulate the Effects of Amylin on c-Fos Expression in the Area Postrema and on Food Intake"],"prefix":"10.1159","volume":"86","author":[{"given":"Signe","family":"Michel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Csilla","family":"Becskei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elif","family":"Erguven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas A.","family":"Lutz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Riediger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2007,8,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1210%2Fer.15.2.163"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2F0006-8993%2891%2991644-G"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2F0196-9781%2891%2990148-I"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2F0031-9384%2894%2990076-0"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2F0031-9384%2895%2902067-5"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.ijo.0801664"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291096-9136%28199706%2914%3A2%2B%3CS14%3A%3AAID-DIA398%3E3.3.CO%3B2-H"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00401833"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2FS1054-3589%2805%2952004-0"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2FS1054-3589%2805%2952008-8"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2FS0026-0495%2897%2990170-0"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2F0306-4522%2894%2990388-3"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2FS0196-9781%2897%2900292-1"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2FS0016-5085%2898%2983064-3"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2FS0304-3940%2802%2900482-2"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2FS0167-0115%2897%2901034-3"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.3109%2F00365529609031632"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2FS0006-8993%2898%2901348-1"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2FS0031-9384%2896%2900531-8"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291098-2299%28199604%2937%3A4%3C231%3A%3AAID-DDR5%3E3.0.CO%3B2-M"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016%2FS0031-9384%2898%2900110-3"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016%2FS0196-9781%2802%2900280-2"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.2337%2Fdiabetes.47.1.93"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016%2FS1054-3589%2805%2952010-6"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1113%2Fjphysiol.2002.018671"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016%2FS0196-9781%2898%2900127-2"}],"container-title":["Neuroendocrinology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/107579","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/107579","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:50:24Z","timestamp":1745463024000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000107579"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":26,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2007,9,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000107579","archive":["Portico"],"relation":{},"ISSN":["0028-3835","1423-0194"],"issn-type":[{"value":"0028-3835","type":"print"},{"value":"1423-0194","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007]]}}}