{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T03:18:26Z","timestamp":1789010306923,"version":"build-2803163510"},"reference-count":28,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>&lt;i&gt;Background\/Aim:&lt;\/i&gt; Recent reports of pulse corticosteroid therapy for alopecia areata (AA) show its efficacy for patients with a history of \u22641 year but not for recalcitrant cases or alopecia totalis\/universalis. The purpose of this study was to evaluate the efficacy and safety of pulse corticosteroid therapy for recent-onset AA patients. &lt;i&gt;Method:&lt;\/i&gt; A total of 139 severe AA patients aged &gt;15 years were included in this study. The duration from the onset of active hair loss was within 12 months for 125 (89.9%) of those patients. &lt;i&gt;Results:&lt;\/i&gt; Of the patients, 72.7% had hair loss on &gt;50% of their scalp area. Among the recent-onset group (duration of AA \u22646 months), 59.4% were good responders (&gt;75% regrowth of alopecia lesions), while 15.8% with &gt;6 months duration showed a good response. Recent-onset AA patients with less severe disease (\u226450% hair loss) responded at a rate of 88.0%, but only 21.4% of recent-onset patients with 100% hair loss responded. No serious adverse effects were observed.<\/jats:p>","DOI":"10.1159\/000107626","type":"journal-article","created":{"date-parts":[[2007,10,2]],"date-time":"2007-10-02T04:53:46Z","timestamp":1191300826000},"page":"320-324","source":"Crossref","is-referenced-by-count":73,"title":["Pulse Corticosteroid Therapy for Alopecia Areata: Study of 139 Patients"],"prefix":"10.1159","volume":"215","author":[{"given":"Takeshi","family":"Nakajima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shigeki","family":"Inui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Itami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2007,10,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.4065%2F70.7.628"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2133.2003.05535.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.0022-202X.2004.23580.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1001%2Fjama.1952.03680060018006"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159%2F000092287"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1159%2F000247268"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-4362.1996.tb03281.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0190-9622%2898%2970009-X"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1159%2F000051642"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaad.2004.10.873"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1186%2F1471-5945-5-11"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-4362.1992.tb03932.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1468-3083.2006.01676.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1016%2FS0190-9622%2808%2981090-0"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159%2F000092831"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaut.2004.08.002"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2133.2000.03464.x"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.it.2004.09.014"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002%2F1529-0131%28199805%2941%3A5%3C761%3A%3AAID-ART2%3E3.0.CO%3B2-M"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1159%2F000246159"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1525-1470.1998.1998015313.x"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.hepres.2005.12.002"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1016%2FS0190-9622%2897%2970342-6"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaad.2005.03.005"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1468-3083.2002.00570_5.x"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaad.2005.09.010"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1001%2Farchderm.141.12.1513"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaad.2006.05.008"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/107626","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/107626","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T22:50:52Z","timestamp":1745448652000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000107626"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":28,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2007,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000107626","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007]]}}}