{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T08:12:46Z","timestamp":1775635966223,"version":"3.50.1"},"reference-count":15,"publisher":"S. Karger AG","issue":"4","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>&lt;i&gt;Objective:&lt;\/i&gt; To investigate if pimecrolimus cream 1% reduces the need for steroids in the long-term management of severe pediatric atopic dermatitis (AD). &lt;i&gt;Methods:&lt;\/i&gt; A total of 184 pediatric patients (aged 2\u201317 years) with a history of severe AD according to Rajka and Langeland were enrolled. Patients were randomized to treatment with pimecrolimus cream or vehicle cream for a 24-week period. Prednicarbate 0.25% was applied as rescue medication. &lt;i&gt;Results:&lt;\/i&gt; Patients on pimecrolimus required steroids on a mean of 29% of study days, compared with 35% of patients on vehicle (p = 0.1841). On the head and neck only, the respective figures were 10 versus 19% (p = 0.0009). In patients enrolled with acute severe disease (Investigator\u2019s Global Assessment \u22674), steroids were used on 28% of the days in the pimecrolimus group compared to 45% in the control group (p = 0.0024). On the head and neck, steroids were used on 10% of study days with pimecrolimus versus 30% with vehicle (p &lt; 0.0001). &lt;i&gt;Conclusion:&lt;\/i&gt; The results indicate that the need for topical steroids on the head and neck is reduced with pimecrolimus cream 1% in the management of severe pediatric AD according to the definition of Rajka and Langeland.<\/jats:p>","DOI":"10.1159\/000107627","type":"journal-article","created":{"date-parts":[[2007,10,2]],"date-time":"2007-10-02T08:53:46Z","timestamp":1191315226000},"page":"325-330","source":"Crossref","is-referenced-by-count":33,"title":["Steroid-Sparing Effect of Pimecrolimus Cream 1% in Children with Severe Atopic Dermatitis"],"prefix":"10.1159","volume":"215","author":[{"given":"Torsten","family":"Zuberbier","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucie","family":"Heinzerling","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Bieber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uwe","family":"Schauer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sven","family":"Klebs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthias","family":"Br\u00e4utigam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2007,10,18]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.2004.06269.x"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1517%2F13543784.9.1.69"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1525-1470.1984.tb01124.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159%2F000248399"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159%2F000065863"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1034%2Fj.1600-0625.2001.100102.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2133.1995.tb08669.x"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007%2Fs11136-004-4231-z"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1468-3083.2005.01249.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159%2F000096195"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1159%2F000245677"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-004-0068-2"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1159%2F000096915"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1468-3083.2006.01383.x"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159%2F000102116"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/107627","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/107627","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:50:53Z","timestamp":1745463053000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000107627"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":15,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2007,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000107627","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007]]}}}