{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T07:09:50Z","timestamp":1761894590074,"version":"3.40.4"},"reference-count":25,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2007,8,30]],"date-time":"2007-08-30T00:00:00Z","timestamp":1188432000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,8,30]],"date-time":"2007-08-30T00:00:00Z","timestamp":1188432000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Pharmacology"],"published-print":{"date-parts":[[2008]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; There is considerable research evidence supporting a palliative role for \u03b3-aminobutyric acid (GABA)-ergic neurotransmission and voltage-gated sodium channel blockade in neuropathic pain conditions. Hence, the present study was undertaken to assess the peripheral analgesic, antiallodynic and antihyperalgesic activities of the synthesized structural analogues of GABA. &lt;i&gt;Methods:&lt;\/i&gt; The screening study included acute tissue injury, chronic constriction injury (CCI), and spinal nerve ligation (SNL) models of neuropathic pain. &lt;i&gt;Results:&lt;\/i&gt; All of the tested compounds sup-pressed the acetic acid-induced writhing response significantly in comparison to the control. In particular, compound JVP-8 was observed to be the most active compound with percent inhibition greater than that of the standard drug aspirin (97.8% inhibition of writhing response as against 97.0% shown by aspirin). In neuropathic pain studies, compound JVP-5 (100 mg\/kg i.p.) emerged as the most active compound affording maximum protection against dynamic allodynia and mechanical hyperalgesia in the CCI model, and against spontaneous pain and mechanical hyperalgesia in SNL rats. &lt;i&gt;Conclusion:&lt;\/i&gt; In this study, we have demonstrated that combining phthalimide pharmacophore with GABA has evolved compounds effective for the treatment of neuropathic pain.<\/jats:p>","DOI":"10.1159\/000107711","type":"journal-article","created":{"date-parts":[[2007,9,10]],"date-time":"2007-09-10T09:50:48Z","timestamp":1189417848000},"page":"21-31","source":"Crossref","is-referenced-by-count":6,"title":["Newer N-Phthaloyl GABA Derivatives with Antiallodynic and Antihyperalgesic Activities in Both Sciatic Nerve and Spinal Nerve Ligation Models of Neuropathic Pain"],"prefix":"10.1159","volume":"81","author":[{"given":"Perumal","family":"Yogeeswari","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jegadeesan Vaigunda","family":"Ragavendran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dharmarajan","family":"Sriram","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramkumar","family":"Kavya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaliappan","family":"Vanitha","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harshini","family":"Neelakantan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2007,8,30]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS0304-3959%2896%2903140-5"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0304-3959%2899%2900154-2"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1124%2Fjpet.302.3.1168"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2F0301-0082%2891%2990036-Z"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1016%2FS0014-2999%2897%2900070-8"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0304-3959%2898%2900239-5"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jpain.2005.09.006"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1021%2Fjm990068t"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2F0304-3959%2888%2990209-6"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.bjp.0705427"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2F0304-3959%2892%2990041-9"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2F0304-3959%2894%2990023-X"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2FS0304-3959%2899%2900111-6"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1054%2Fjpai.2000.19948"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2FS0006-8993%2899%2901564-4"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2FS0306-4522%2896%2900341-7"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2F0304-3959%2889%2990160-7"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016%2F0028-3908%2894%2990149-X"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2FS0304-3959%2896%2903249-6"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1124%2Fjpet.106.104737"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.neuropharm.2005.12.008"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.ejphar.2006.03.008"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1021%2Fjm030498q"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1016%2F0753-3322%2894%2990083-3"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1528-1157.1995.tb02567.x"}],"container-title":["Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/107711","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/107711","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:51:51Z","timestamp":1745463111000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000107711"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8,30]]},"references-count":25,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2007,11,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000107711","archive":["Portico"],"relation":{},"ISSN":["0031-7012","1423-0313"],"issn-type":[{"type":"print","value":"0031-7012"},{"type":"electronic","value":"1423-0313"}],"subject":[],"published":{"date-parts":[[2007,8,30]]}}}