{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:04:29Z","timestamp":1777525469517,"version":"3.51.4"},"reference-count":27,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Kidney Blood Press Res"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>&lt;i&gt;Background\/Aims:&lt;\/i&gt; The urinary concentration of the monocyte chemoattractant protein-1 (uMCP-1) chemokine is increased in several proteinuric and\/or inflammatory renal diseases. In the present study, we evaluated the association between uMCP-1 and renal function, proteinuria, glomerular and interstitial macrophage infiltration, and renal fibrosis in patients with primary and secondary glomerulopathies diagnosed by renal biopsy. &lt;i&gt;Methods:&lt;\/i&gt; Thirty-seven patients aged 32.6 \u00b1 7.7 years were studied. uMCP-1 was determined by ELISA. Renal macrophage expression (CD68 positive cells) is reported as number of macrophages\/10&lt;sup&gt;4&lt;\/sup&gt; \u00b5m&lt;sup&gt;2&lt;\/sup&gt; of the cortical tubulointerstitial (TI) area or of glomerular capillary tuft area. Cortical interstitial fibrosis was quantitated by PicroSirius red staining under polarized light by a computerized manner. &lt;i&gt;Results:&lt;\/i&gt; The uMCP-1 ratio (pg\/ml\/urinary creatinine mg\/ml) was positively correlated (Spearman coefficient) with proteinuria (r = 0.4629; p &lt; 0.005) and number of macrophages in the cortical TI area (r = 0.64; p = 0.0005), and negatively correlated with creatinine clearance (r = \u20130.4877; p &lt; 0.001). The uMCP-1 ratio was not significantly correlated with number of macrophages\/glomerular capillary tuft area (r = 0.27; p = 0.19) or with percent cortical interstitial fibrosis (r = 0.08; p = 0.62). &lt;i&gt;Conclusions:&lt;\/i&gt; The uMCP-1 excretion is a biomarker of the inflammatory activity of the TI area, and does not reflect chronic interstitial damage.<\/jats:p>","DOI":"10.1159\/000107806","type":"journal-article","created":{"date-parts":[[2007,9,5]],"date-time":"2007-09-05T12:18:43Z","timestamp":1188994723000},"page":"306-313","source":"Crossref","is-referenced-by-count":12,"title":["Urinary Excretion of Monocyte Chemoattractant Protein-1: A Biomarker of Active Tubulointerstitial Damage in Patients with Glomerulopathies"],"prefix":"10.1159","volume":"30","author":[{"given":"M\u00e1rcio","family":"Dantas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elen","family":"Almeida 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