{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T10:05:43Z","timestamp":1778666743953,"version":"3.51.4"},"reference-count":21,"publisher":"S. Karger AG","issue":"5","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord"],"published-print":{"date-parts":[[2007]]},"abstract":"<i>Background:<\/i> Behavioural and psychological symptoms of dementia (BPSDs) are common. It is unclear whether associations are stronger with the absolute cognitive level or that relative to premorbid mental ability. <i>Methods:<\/i> The Neuropsychiatric Inventory (NPI) was administered to carers of patients with Alzheimer\u2019s disease (AD). Patients underwent cognitive testing with the National Adult Reading Test (NART) to estimate premorbid IQ and 6 tests of current cognitive function. <i>Results:<\/i> 556 patients, mean age 77.3 years, had NPI scores. The total NPI score correlated significantly with most cognitive test scores, but multi-linear regression identified NART-IQ as the only significant cognitive predictor (\u03b2 = \u20130.17, p = 0.008). Principal component analysis of the 10 NPI domains extracted 3 components corresponding to mood, frontal and psychotic factors. The NPI mood factor correlated significantly with NART-IQ (\u03c1 = \u20130.14, p = 0.014) and lexical verbal fluency (\u03c1 = \u20130.09, p = 0.034) only. The NPI frontal factor correlation with NART-IQ approached significance (\u03c1 = \u20130.11, p = 0.053). The NPI psychotic factor correlated significantly with the Mini-Mental State Examination (\u03c1 = \u20130.15, p < 0.001) and the Hopkins verbal learning test (\u03c1 = \u20130.11, p = 0.013) scores. <i>Conclusion:<\/i> The relationship between BPSDs and cognition in AD is weak and largely explained by premorbid IQ. There is a stronger relationship between current cognition and psychotic symptoms.<\/jats:p>","DOI":"10.1159\/000108632","type":"journal-article","created":{"date-parts":[[2007,9,21]],"date-time":"2007-09-21T12:08:04Z","timestamp":1190376484000},"page":"343-347","source":"Crossref","is-referenced-by-count":26,"title":["Relationship between Behavioural and Psychological Symptoms of Dementia and Cognition in Alzheimer\u2019s Disease"],"prefix":"10.1159","volume":"24","author":[{"given":"John M.","family":"Starr","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane","family":"Lonie","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2007,9,20]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1176%2Fappi.ajp.157.5.708"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2FS0733-8619%2805%2970228-0"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00415-004-0403-6"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jns.2005.04.014"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1159%2F000084552"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002%2Fgps.448"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1159%2F000017113"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002%2Fgps.1668"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1532-5415.2007.01143.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2F0022-3956%2875%2990026-6"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1080%2F13854049108403297"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1159%2F000106735"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1212%2FWNL.44.12.2308"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159%2F000067972"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1002%2Fana.20637"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2806%2969113-7"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00127-003-0685-5"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1017%2FS1041610298005468"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1212%2F01.wnl.0000168907.44632.55"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1097%2F00001756-200303030-00010"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1002%2Fgps.509"}],"container-title":["Dementia and Geriatric Cognitive Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/108632","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/108632","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:01:20Z","timestamp":1745463680000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000108632"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":21,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2007,10,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000108632","archive":["Portico"],"relation":{},"ISSN":["1420-8008","1421-9824"],"issn-type":[{"value":"1420-8008","type":"print"},{"value":"1421-9824","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007]]}}}