{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T01:10:52Z","timestamp":1783473052628,"version":"3.55.0"},"reference-count":21,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2007,9,21]],"date-time":"2007-09-21T00:00:00Z","timestamp":1190332800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,9,21]],"date-time":"2007-09-21T00:00:00Z","timestamp":1190332800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Nephron Clin Pract"],"abstract":"<i>Background:<\/i> Disturbances in mineral and vitamin D metabolism, which affect parathyroid hormone (PTH) synthesis, are well recognized in patients receiving dialysis. However, it is unclear at what stage of chronic kidney disease (CKD) these abnormalities develop. <i>Methods:<\/i> The associations between CKD stages 3 and 5, and alterations of calcium, phosphate, vitamin D and PTH concentrations were assessed in 249 patients (mean age 61 years, 66% male) and 79 age- and sex-matched healthy controls. <i>Results:<\/i> As compared to controls, serum phosphate concentrations were elevated among CKD patients (1.40 vs. 1.11 mmol\/l; p < 0.0001). And levels of both 25-hydroxyvitamin D (42.1 vs. 60.4 nmol\/l; p < 0.0001) and 1,25-dihydroxyvitamin D (58.2 vs. 119.5 pmol\/l; p < 0.0001) were lower among patients with CKD, even among those with only stage 3 CKD and despite 73% of patients receiving vitamin D supplements. The ratio of 1,25-dihydroxy- to 25-hydroxyvitamin D was lower than controls, even among patients with stage 3 CKD (p = 0.0001), and this ratio diminished with advancing renal impairment. Concomitant elevations were observed in intact PTH (13.8 vs. 4.2 pmol\/l; p < 0.0001) and whole PTH (7.9 vs. 2.7 pmol\/l; p < 0.0001). <i>Conclusion:<\/i> Impaired conversion of 25-hydroxy- to 1,25-dihydroxyvitamin D is an early feature of renal disease, and progresses as renal function deteriorates.<\/jats:p>","DOI":"10.1159\/000108652","type":"journal-article","created":{"date-parts":[[2007,9,21]],"date-time":"2007-09-21T12:14:03Z","timestamp":1190376843000},"page":"c109-c116","source":"Crossref","is-referenced-by-count":35,"title":["Cross-Sectional Analysis of Abnormalities of Mineral Homeostasis, Vitamin D and Parathyroid Hormone in a Cohort of Pre-Dialysis Patients"],"prefix":"10.1159","volume":"107","author":[{"given":"Daniel","family":"Zehnder","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin J.","family":"Landray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David C.","family":"Wheeler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Fraser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Blackwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Nuttall","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sue V.","family":"Hughes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Townend","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Ferro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Baigent","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Hewison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2007,9,21]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1210%2Fjcem-67-5-876"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.1999.0550031019.x"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1053%2Fajkd.1998.v31.pm9531176"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2F17.8.1419"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1053%2Fj.ajkd.2005.02.029"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.61.s80.26.x"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2F17.11.1875"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1093%2Fndt%2Fgfg349"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI106517"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1159%2F000081023"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038%2F228764a0"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.2003.00114.x"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1210%2Fen.143.2.587"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1681%2FASN.2005010052"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.1999.00480.x"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9150(85)90070-X"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI118061"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199212033272305"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1523-1755.2004.09103.x"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1523-1755.2005.00513.x"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1159%2F000180580"}],"container-title":["Nephron Clinical Practice"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/108652","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/108652","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:01:31Z","timestamp":1745463691000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000108652"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,9,21]]},"references-count":21,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2007,11,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000108652","archive":["Portico"],"relation":{},"ISSN":["1660-2110"],"issn-type":[{"value":"1660-2110","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,9,21]]}}}