{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:22:06Z","timestamp":1761708126597,"version":"3.40.4"},"reference-count":18,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2007,9,24]],"date-time":"2007-09-24T00:00:00Z","timestamp":1190592000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,9,24]],"date-time":"2007-09-24T00:00:00Z","timestamp":1190592000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neonatology"],"published-print":{"date-parts":[[2008]]},"abstract":"<i>Background:<\/i> Leptin is produced predominantly by white adipocytes; in adults it regulates appetite and energy expenditure but its role in the neonate remains to be fully established. <i>Objectives:<\/i> To examine the effects of acute administration of recombinant human leptin on the endocrine profile and thermoregulation of neonatal pigs. <i>Methods:<\/i> 24 pairs of siblings (n = 48) were administered with either a single dose (4 \u00b5g ml<sup>\u20131<\/sup> kg<sup>\u20131<\/sup> body weight) of leptin (L: n = 24) or a placebo (P: n = 24) on day 6 of neonatal life. Rectal temperature was recorded, and tissue samples were taken at 1 (n = 12), 2 (n = 12), 4 (n = 12) or 6 (n = 12) hours post-administration. Plasma concentrations of hormones and metabolites were determined in conjunction with messenger RNA (mRNA) for leptin and uncoupling protein-2. <i>Results:<\/i> Plasma leptin increased following leptin administration, and differences in concentrations of insulin, thyroxine and non-esterified fatty acids were observed between the two groups. Initially, rectal temperature decreased in L pigs but returned to start values by 1.5 h. This decline in rectal temperature was delayed in placebo animals, resulting in differences between treatments at 1.5 and 2 h. <i>Conclusions:<\/i> Acute leptin administration alters the endocrine profile of pigs and influences the thermoregulatory ability of the neonate.<\/jats:p>","DOI":"10.1159\/000108926","type":"journal-article","created":{"date-parts":[[2007,9,27]],"date-time":"2007-09-27T06:29:49Z","timestamp":1190874589000},"page":"171-177","source":"Crossref","is-referenced-by-count":5,"title":["Effect of Acute Administration of Recombinant Human Leptin during the Neonatal Period on Body Temperature and Endocrine Profile of the Piglet"],"prefix":"10.1159","volume":"93","author":[{"given":"J.C.","family":"Litten","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Mostyn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Laws","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.M.","family":"Corson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.E.","family":"Symonds","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L.","family":"Clarke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2007,9,24]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038%2F27376"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1071%2FR97016"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1002%2F%28SICI%291096-8644%281998%29107%3A27%2B%3C177%3A%3AAID-AJPA7%3E3.0.CO%3B2-B"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1159%2F000080107"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1677%2Fjoe.0.1590349"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.4141%2Fcjas96-075"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2FS0378-1119%2800%2900061-5"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1677%2Fjoe.1.05448"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1080%2F10495399709525882"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1203%2F00006450-200207000-00016"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2F0031-9384%2893%2990378-S"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI118551"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.cbpb.2004.02.005"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1006%2Fbbrc.1997.7274"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2FS0739-7240%2897%2900064-7"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1038%2F382250a0"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1210%2Fen.139.1.8"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1210%2Fen.2005-0581"}],"container-title":["Neonatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/108926","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/108926","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:05:06Z","timestamp":1745463906000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000108926"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,9,24]]},"references-count":18,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2008,3,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000108926","archive":["Portico"],"relation":{},"ISSN":["1661-7800","1661-7819"],"issn-type":[{"type":"print","value":"1661-7800"},{"type":"electronic","value":"1661-7819"}],"subject":[],"published":{"date-parts":[[2007,9,24]]}}}