{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:27:59Z","timestamp":1791156479675,"version":"4.1.0"},"reference-count":28,"publisher":"S. Karger AG","issue":"3","license":[{"start":{"date-parts":[[2007,10,4]],"date-time":"2007-10-04T00:00:00Z","timestamp":1191456000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,10,4]],"date-time":"2007-10-04T00:00:00Z","timestamp":1191456000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Int Arch Allergy Immunol"],"published-print":{"date-parts":[[2008]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Many types of fermented food are consumed in Japan. Although some are produced by plant-origin lactic-acid bacteria (LAB) fermentation, the physiological functions of such bacteria remain unclear. We therefore isolated LAB of plant origin from Kyoto pickles and determined the immunological activity of heat-killed preparations of plant-origin LAB. &lt;i&gt;Methods:&lt;\/i&gt; The &lt;i&gt;Lactobacillus pentosus&lt;\/i&gt; strain S-PT84 was selected from among 16 LAB of plant origin as the strongest interleukin (IL)-12-inducing strain. IL-12- and IL-10-inducing activities were determined with macrophages from BALB\/c mice. The in vivo immunomodulating effect of S-PT84was determined with BALB\/c mice fed S-PT84. The antiallergic activity of S-PT84 was examined in ovalbumin (OVA)\/alum-administered BALB\/c mice. &lt;i&gt;Results:&lt;\/i&gt; The &lt;i&gt;L. pentosus&lt;\/i&gt; strain S-PT84 induced production of both IL-12 and IL-10 in vitro. S-PT84 enhanced splenic natural-killer activity and modulated the T helper (Th) type 1\/type 2 balance toward a Th1-dominant state. In the OVA-induced allergy model, orally administered S-PT84 lowered serum IgE levels and suppressed active cutaneous anaphylaxis reaction and splenic IL-4 production. IL-10 production from splenocytes of OVA-immunized mice was upregulated by feeding S-PT84. &lt;i&gt;Conclusions:&lt;\/i&gt; Despite heat-killing, S-PT84 exhibited antiallergic effects by modulating the Th1\/Th2 balance and inducing regulatory T cells. The &lt;i&gt;L. pentosus&lt;\/i&gt; strain S-PT84, which is of plant origin and isolated from a traditional Japanese food, is expected to be useful for treatment of many immune diseases including allergies, tumors, infectious diseases and auto-immune diseases.<\/jats:p>","DOI":"10.1159\/000109294","type":"journal-article","created":{"date-parts":[[2007,10,4]],"date-time":"2007-10-04T05:47:16Z","timestamp":1191476836000},"page":"249-257","source":"Crossref","is-referenced-by-count":102,"title":["Antiallergic Effects of Lactobacillus pentosus Strain S-PT84 Mediated by Modulation of Th1\/Th2 Immunobalance and Induction of IL-10 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