{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T09:13:02Z","timestamp":1768295582538,"version":"3.49.0"},"reference-count":20,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2007,11,28]],"date-time":"2007-11-28T00:00:00Z","timestamp":1196208000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,11,28]],"date-time":"2007-11-28T00:00:00Z","timestamp":1196208000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dermatology"],"published-print":{"date-parts":[[2008]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Vulvodynia is a fairly common dermatological symptom that often interferes with the personal, social and working activities of affected women and results in a significant loss of their quality of life. It is a persistent and tedious clinical disorder which is often resistant to conventional treatments. &lt;i&gt;Objectives:&lt;\/i&gt; The aim of this study is to evaluate the main clinical signs, associated psychopathological disorders and outcome after antidepressant treatment of patients with vulvodynia. &lt;i&gt;Methods:&lt;\/i&gt; Eighty patients were included. Clinical characteristics and psychopathological profiles were determined by appropriate instruments. The improvement of clinical symptoms after combined antidepressant drug therapy was also evaluated. &lt;i&gt;Results:&lt;\/i&gt; Pain (70%), burning (63.7%), dyspareunia (57.5%) and stinging (56.2%) were the most commonly reported symptoms. Most patients (56.5%) showed anxiety, and 52.2% of them were reported as having a depression disorder. When evaluated by psychometric tools, 81.4% of patients scored &gt;150 on the Life Event Scale, which means a risk &gt;50% of suffering an illness in the near future, and patients\u2019 scores in the Dermatology Life Quality Index showed higher values than the mean of the Spanish validation group. After 6 months of combined treatment with escitalopram (10\u201320 mg\/day), perfenazine (2\u20134 mg\/day) and amytriptiline (10 mg\/day), a complete remission of the clinical symptoms was achieved in 41% of patients. In contrast, only 12% of patients who did not follow drug treatment reported a complete resolution of the clinical symptoms. &lt;i&gt;Conclusions:&lt;\/i&gt; Our results seem to confirm that vulvodynia is associated with psychiatric co-morbidity such as stress and depression. The study highlights that the psychiatric treatment may be a useful option to improve clinical symptoms. Whether these patients should be evaluated for depression or be referred to a psychiatrist, remains to be investigated.<\/jats:p>","DOI":"10.1159\/000109354","type":"journal-article","created":{"date-parts":[[2007,11,19]],"date-time":"2007-11-19T13:06:21Z","timestamp":1195477581000},"page":"24-30","source":"Crossref","is-referenced-by-count":32,"title":["Clinical Characteristics and Psychopathological Profile of Patients with Vulvodynia: An Observational and Descriptive Study"],"prefix":"10.1159","volume":"216","author":[{"given":"M.J.","family":"Trib\u00f3","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Andi\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Ros","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Gilaberte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Gallardo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Toll","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Ferr\u00e1n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Bulbena","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.M.","family":"Pujol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.E.","family":"Ba\u00f1os","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2007,11,28]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.rigp.2003.11.005"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00105-005-0970-1"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1468-3083.1996.tb00608.x"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1526-4637.2004.04060.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1080%2F01674820400024463"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1002%2Fnur.4770130405"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097%2F00002508-200112000-00012"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2F0022-3999%2867%2990010-4"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1600-0447.1983.tb09716.x"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.2044-8341.1959.tb00467.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2230.1994.tb01167.x"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS0163-8343%2803%2900043-4"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2F0022-3956%2888%2990024-6"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159%2F000082570"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1024%2F0040-5930.61.5.308"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1365-2133.1999.03112.x"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1159%2F000096190"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1097%2F00006254-199508000-00023"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1016%2F0029-7844%2896%2900080-4"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2804%2915842-X"}],"container-title":["Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/109354","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/109354","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:10:22Z","timestamp":1745464222000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000109354"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,11,28]]},"references-count":20,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2007,11,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000109354","archive":["Portico"],"relation":{},"ISSN":["1018-8665","1421-9832"],"issn-type":[{"value":"1018-8665","type":"print"},{"value":"1421-9832","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,11,28]]}}}