{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T18:14:30Z","timestamp":1791224070289,"version":"4.1.0"},"reference-count":23,"publisher":"S. Karger AG","issue":"1-2","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Cytogenet Genome Res"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>We describe a case of an 87-year-old woman with myelodysplastic syndrome (MDS) in transformation. At presentation, the patient suffered from refractory anemia with excess of blasts (RAEB). The karyotype showed a clone with 3 to &gt;20 double minutes (dmin) that were &lt;i&gt;MYC&lt;\/i&gt;-positive and, in addition, a cryptic deletion of &lt;i&gt;MYC&lt;\/i&gt; on one of the chromosome 8 homologs. The dmin varied both in size and in fluorescence intensity for the &lt;i&gt;MYC&lt;\/i&gt; probe following FISH. After six months, the disease had progressed to refractory anemia with excess of blasts in transformation (RAEBT). The corresponding karyotype showed a second cell line with two markers that appeared like rings and, again, a cryptic &lt;i&gt;MYC&lt;\/i&gt; deletion on one of the chromosome 8 homologs. The markers contained centromeres and amplified &lt;i&gt;MYC&lt;\/i&gt; sequences. The deletion of &lt;i&gt;MYC&lt;\/i&gt; on one of the chromosome 8 homologs and the variable sizes and intensities of the dmin supports an episome model for dmin formation. Chronologically, the &lt;i&gt;MYC&lt;\/i&gt;-positive dmin appeared first, followed by the appearance of &lt;i&gt;MYC&lt;\/i&gt;-positive marker chromosomes, suggesting that the dmin may have evolved to form homogeneously staining regions (hsr) in vivo.<\/jats:p>","DOI":"10.1159\/000109619","type":"journal-article","created":{"date-parts":[[2007,12,14]],"date-time":"2007-12-14T10:31:44Z","timestamp":1197628304000},"page":"53-59","source":"Crossref","is-referenced-by-count":11,"title":["Double minutes (dmin) and homogeneously staining regions (hsr) in myeloid disorders: a new case suggesting that dmin form hsr in vivo"],"prefix":"10.1159","volume":"119","author":[{"given":"K.S.","family":"Reddy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2007,12,14]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1038%2Fng1215"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016%2F0014-4827%2880%2990012-9"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.2006410"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016%2FS0140-6736%2865%2990131-5"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.91.14.6674"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2F0165-4608%2880%2990034-5"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.semcancer.2006.10.007"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1101%2Fgad.1095203"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.0407512102"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1615%2FJEnvPathToxOncol.v22.i3.30"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.onc.1205566"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS0165-4608%2898%2900133-2"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.cell.2006.04.042"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.onc.1202746"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1016%2F0165-4608%2887%2990152-X"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1016%2FS0003-9861%2803%2900294-7"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.yexcr.2004.09.001"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1146%2Fannurev.bi.53.070184.002311"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1093%2Fhmg%2Fddl010"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.85.13.4804"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.89.17.8165"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1101%2Fgad.313104"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1101%2Fgad.5.2.160"}],"container-title":["Cytogenetic and Genome Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/109619","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/109619","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T03:13:25Z","timestamp":1745464405000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000109619"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":23,"journal-issue":{"issue":"1-2","published-online":{"date-parts":[[2007,12,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000109619","archive":["Portico"],"relation":{},"ISSN":["1424-8581","1424-859X"],"issn-type":[{"value":"1424-8581","type":"print"},{"value":"1424-859X","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007]]}}}