{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T05:07:20Z","timestamp":1778908040140,"version":"3.51.4"},"reference-count":20,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Dement Geriatr Cogn Disord"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Alzheimer disease (AD) is under substantial genetic influence. To better understand the genetic influence on component phenotypes of AD, we estimated the heritability (h&lt;sup&gt;2&lt;\/sup&gt;) of abstract reasoning and examined its relation with apolipoprotein &amp;#917;4 (APOE-&amp;#917;4). &lt;i&gt;Methods:&lt;\/i&gt; We studied abstract reasoning in 1,116 individuals from 210 Caribbean Hispanic families with late onset AD, using the similari- ties subtest scores from the Wechsler Adult Intelligence Scale. We computed h&lt;sup&gt;2&lt;\/sup&gt;, then performed analysis of variance to examine the effect of APOE-&amp;#917;4. &lt;i&gt;Results:&lt;\/i&gt; Abstract reasoning was highly heritable (h&lt;sup&gt;2&lt;\/sup&gt;&lt;sub&gt;unadjusted&lt;\/sub&gt; = 79.9%). After adjusting for covariates, the h&lt;sup&gt;2&lt;\/sup&gt; was reduced to 32.6%, with education accounting for 40.8% of the variance. The APOE-&amp;#917;4 allele had no effect. &lt;i&gt;Conclusion:&lt;\/i&gt; Abstract reasoning was strongly influenced by genetic factors and education. Genes other than &lt;i&gt;APOE&lt;\/i&gt; contribute to the inheritance of abstract reasoning ability.<\/jats:p>","DOI":"10.1159\/000109765","type":"journal-article","created":{"date-parts":[[2007,10,18]],"date-time":"2007-10-18T10:17:51Z","timestamp":1192702671000},"page":"411-417","source":"Crossref","is-referenced-by-count":9,"title":["The Heritability of Abstract Reasoning in Caribbean Latinos with Familial Alzheimer Disease"],"prefix":"10.1159","volume":"24","author":[{"given":"Beverly","family":"Johnson","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincent","family":"Santana","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Schupf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-X","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaakov","family":"Stern","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Mayeux","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph H.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2007,10,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.8091226"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1093%2Fbrain%2Fawh451"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1001%2Farchneur.57.6.808"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1176%2Fappi.ajgp.13.2.134"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.276.5318.1560"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1037%2F0882-7974.16.2.272"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1176%2Fappi.ajp.160.4.636"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016%2FS0065-2660%2801%2942015-3"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.7195071"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2F0160-2896%2884%2990012-6"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1001%2Farchneur.59.1.87"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1086%2F324773"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1086%2F301844"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.7195071"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.290.5500.2303"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.290.5500.2302"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1126%2Fscience.290.5500.2304"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1037%2F%2F0894-4105.7.3.273"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1017%2FS1355617702813248"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1076%2Fjcen.25.5.614.14581"}],"container-title":["Dementia and Geriatric Cognitive Disorders"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/109765","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/109765","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T01:57:52Z","timestamp":1745459872000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000109765"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":20,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2007,11,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000109765","archive":["Portico"],"relation":{},"ISSN":["1420-8008","1421-9824"],"issn-type":[{"value":"1420-8008","type":"print"},{"value":"1421-9824","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007]]}}}