{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,17]],"date-time":"2025-11-17T08:07:22Z","timestamp":1763366842755,"version":"3.40.4"},"reference-count":14,"publisher":"S. Karger AG","issue":"2","license":[{"start":{"date-parts":[[2007,10,16]],"date-time":"2007-10-16T00:00:00Z","timestamp":1192492800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,10,16]],"date-time":"2007-10-16T00:00:00Z","timestamp":1192492800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Vasc Res"],"published-print":{"date-parts":[[2008]]},"abstract":"<i>Background:<\/i> Magnetic resonance imaging (MRI) contrast agents that specifically detect atherosclerotic plaque may be useful for the noninvasive detection of the plaque. We have recently developed a new contrast agent, Evans blue-DTPA-gadolinium (EB-DTPA-Gd), which selectively accumulates vascular lesions with endothelial removal. In this study, we examined whether EB-DTPA-Gd is also useful for in vivo imaging of atherosclerotic plaques. <i>Methods:<\/i> We used male apolipoprotein-E-deficient (ApoE\u2013\/\u2013) mice of different ages (3, 6 and 12 months old) and age-matched male wild-type mice. After a single intravenous administration of EB-DTPA-Gd (160 \u00b5<i>M<\/i>\/kg body weight), MRI T<sub>1<\/sub> signal was obtained in vivo. <i>Results:<\/i> Increased signal intensity in the aortic wall was noted within 10\u201320 min after intravenous injection of EB-DTPA-Gd and was maintained for 30 min. The MRI enhancement in the aorta of ApoE\u2013\/\u2013 mice was increased in accordance with age, whereas no such enhancement was noted in wild-type mice. Histological examination demonstrated that there was a topological correlation between the site of MRI enhancement and that of atherosclerotic plaque. <i>Conclusions:<\/i> These results indicate that EB-DTPA-Gd is a useful MRI contrast medium for the in vivo detection of atherosclerotic plaques.<\/jats:p>","DOI":"10.1159\/000109930","type":"journal-article","created":{"date-parts":[[2007,10,18]],"date-time":"2007-10-18T10:17:51Z","timestamp":1192702671000},"page":"123-128","source":"Crossref","is-referenced-by-count":9,"title":["In vivo Magnetic Resonance Imaging of Atherosclerotic Lesions with a Newly Developed Evans Blue-DTPA-Gadolinium Contrast Medium in Apolipoprotein-E-Deficient Mice"],"prefix":"10.1159","volume":"45","author":[{"given":"Satoshi","family":"Yasuda","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenjiro","family":"Ikuta","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toyokazu","family":"Uwatoku","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiji","family":"Oi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohtaro","family":"Abe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fuminori","family":"Hyodo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kengo","family":"Yoshimitsu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kohtaro","family":"Sugimura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideo","family":"Utsumi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshiki","family":"Katayama","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Shimokawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2007,10,16]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM199901143400207"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1006%2Fjmcc.1998.0841"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jacc.2005.11.092"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038%2Fncpcardio0378"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1161%2F01.CIR.0000155618.37779.A0"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1016%2FS0165-5728%2899%2900248-9"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1002%2F1522-2594%28200012%2944%3A6%3C867%3A%3AAID-MRM7%3E3.0.CO%3B2-P"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1002%2F1522-2594%28200009%2944%3A3%3C433%3A%3AAID-MRM14%3E3.0.CO%3B2-9"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.2116%2Fanalsci.20.5"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.bmcl.2004.03.066"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097%2F01.fjc.0000159657.93922.cb"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1016%2FS0008-6363%2803%2900353-5"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007%2Fs10334-004-0055-7"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1097%2F01.rli.0000187609.78338.dc"}],"container-title":["Journal of Vascular Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/109930","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/109930","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T01:59:40Z","timestamp":1745459980000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000109930"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10,16]]},"references-count":14,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2008,2,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000109930","archive":["Portico"],"relation":{},"ISSN":["1018-1172","1423-0135"],"issn-type":[{"type":"print","value":"1018-1172"},{"type":"electronic","value":"1423-0135"}],"subject":[],"published":{"date-parts":[[2007,10,16]]}}}