{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T06:19:39Z","timestamp":1789193979823,"version":"build-2803163510"},"reference-count":16,"publisher":"S. Karger AG","issue":"1","license":[{"start":{"date-parts":[[2007,10,17]],"date-time":"2007-10-17T00:00:00Z","timestamp":1192579200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,10,17]],"date-time":"2007-10-17T00:00:00Z","timestamp":1192579200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Am J Nephrol"],"published-print":{"date-parts":[[2008]]},"abstract":"<jats:p>The effects of long-term diabetes in the presence of established nephropathy on tubular function remains poorly understood. We evaluated the levels of the main sodium and water transport proteins expressed in the kidney after long-term (8 weeks) of streptozotocin (STZ)-induced type 1 diabetes mellitus (DM) in untreated (D) and insulin (4 U\/s.c.\/day)-treated (D+I) rats. D animals presented upregulation (\u223c4.5-fold) of Na\/glucose cotransporter (SGLT1), whereas the \u03b1-subunit of the epithelial sodium channel (\u03b1-ENaC) and aquaporin 1 (AQP1) were downregulated (\u223c20 and 30% respectively) with no change in the Na\/H exchanger (NHE3), Na\/Cl cotransporter (TSC) and AQP2. Insulin replacement partially prevented these alterations and caused increases in the expression of \u03b1-ENaC and AQP2. These effects suggest an action of insulin in the tubular transport properties. The upregulation of SGLT1 may constitute a mechanism to prevent greater glucose losses in the urine but it may result in glucotoxicity to the proximal epithelial cells contributing to the diabetic nephropathy. The decrease of \u03b1-ENaC in D animals may compensate for the increased sodium reabsorption via SGLT1 resulting in discrete natriuresis. DM-induced polyuria was not due to changes in AQP2 expression.<\/jats:p>","DOI":"10.1159\/000109967","type":"journal-article","created":{"date-parts":[[2007,10,18]],"date-time":"2007-10-18T10:17:51Z","timestamp":1192702671000},"page":"107-114","source":"Crossref","is-referenced-by-count":34,"title":["Effect of Long-Term Type 1 Diabetes on Renal Sodium and Water Transporters in Rats"],"prefix":"10.1159","volume":"28","author":[{"given":"Daniela B.","family":"Vidotti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carine P.","family":"Arnoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgar","family":"Maquigussa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirian A.","family":"Boim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"127","published-online":{"date-parts":[[2007,10,17]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.96.18.10397"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1038%2Fki.1981.33"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1152%2Fajprenal.00208.2003"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1111%2Fj.1365-2362.2005.01497.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1038%2Fki.1990.95"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1172%2FJCI114700"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1097%2F01.ASN.0000024436.00520.D8"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1007%2Fs001250051671"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00232-001-0036-y"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1523-1755.1999.00721.x"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.amjhyper.2006.05.012"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1139%2Fcjpp-78-9-721"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1046%2Fj.1440-1681.2002.03619.x"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.2337%2Fdiabetes.41.3.286"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1007%2Fs11892-007-0007-5"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1152%2Fajpcell.00486.2005"}],"container-title":["American Journal of Nephrology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/109967","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/109967","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:00:05Z","timestamp":1745460005000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000109967"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10,17]]},"references-count":16,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2007,11,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000109967","archive":["Portico"],"relation":{},"ISSN":["0250-8095","1421-9670"],"issn-type":[{"value":"0250-8095","type":"print"},{"value":"1421-9670","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,10,17]]}}}