{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:56:06Z","timestamp":1745470566716,"version":"3.40.4"},"reference-count":17,"publisher":"S. Karger AG","issue":"6","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chemotherapy"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; The optimum regimen for advanced gastric cancer requires definition. This multicentre phase II study evaluated docetaxel-cisplatin combination in advanced gastric cancer. &lt;i&gt;Methods:&lt;\/i&gt; Chemotherapy-na\u00efve patients with locally advanced or metastatic disease received docetaxel plus cisplatin (75\/75 mg\/m&lt;sup&gt;2&lt;\/sup&gt;) every 21 days for up to 9 cycles. Endpoints included tumour response, time to progression, overall survival and toxicity. &lt;i&gt;Results:&lt;\/i&gt; Of 113 patients recruited, 88 were completely evaluable. The median age was 58 years, and most patients had metastatic disease. The overall response rate was 29.6%. Five patients (5.7%) achieved a complete response and 21 patients (23.9%) had a partial response. Tumour control, including stable disease, was achieved in 57 patients (64.8%). The median time to progression and median overall survival time was 4.8 and 8.7 months, respectively. The major toxicity was haematological: 37.5% of patients experienced grade 3\u20134 neutropenia, whereas febrile neutropenia was observed in only 2% of patients. &lt;i&gt;Conclusion:&lt;\/i&gt; Docetaxel-cisplatin was active with a predictable and manageable toxicity profile.<\/jats:p>","DOI":"10.1159\/000110042","type":"journal-article","created":{"date-parts":[[2007,10,24]],"date-time":"2007-10-24T07:36:47Z","timestamp":1193211407000},"page":"454-460","source":"Crossref","is-referenced-by-count":4,"title":["A Multicentre Phase II Study of Docetaxel plus Cisplatin for the Treatment of Advanced Gastric Cancer"],"prefix":"10.1159","volume":"53","author":[{"given":"J.","family":"Fahlke","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Ridwelski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Hribaschek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Stuebs","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Kettner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.","family":"Quietzsch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Assmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Deist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U.","family":"Keilholz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Lippert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2007,10,23]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016%2FS1470-2045%2801%2900486-7"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1002%2F1097-0142%2819930701%2972%3A1%3C37%3A%3AAID-CNCR2820720109%3E3.0.CO%3B2-P"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1038%2Fbjc.1995.114"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1023%2FA%3A1008243606668"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1097%2F00042737-200403000-00003"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1634%2Ftheoncologist.9-3-282"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1038%2Fsj.bjc.6690350"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1097%2F00000421-200202000-00015"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016%2FS0959-8049%2898%2900262-7"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1634%2Ftheoncologist.9-suppl_2-9"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1023%2FA%3A1008328501128"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1023%2FA%3A1008342013224"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1007%2Fs10120-002-0209-0"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1159%2F000094869"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1159%2F000094769"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1200%2FJCO.2005.17.376"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1093%2Fannonc%2Fmdh187"}],"container-title":["Chemotherapy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/110042","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/110042","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:00:48Z","timestamp":1745460048000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000110042"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":17,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2007,11,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000110042","archive":["Portico"],"relation":{},"ISSN":["0009-3157","1421-9794"],"issn-type":[{"type":"print","value":"0009-3157"},{"type":"electronic","value":"1421-9794"}],"subject":[],"published":{"date-parts":[[2007]]}}}