{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:56:22Z","timestamp":1745470582471,"version":"3.40.4"},"reference-count":28,"publisher":"S. Karger AG","issue":"Suppl. 5","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"},{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.karger.com\/Services\/SiteLicenses"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Horm Res Paediatr"],"published-print":{"date-parts":[[2007]]},"abstract":"<jats:p>&lt;i&gt;Background:&lt;\/i&gt; Nine distinct genetic conditions have been identified in the last 12 years causing neonatal diabetes mellitus through failure of normal pancreatic development, islet cell dysfunction or \u03b2-cell destruction. This review will focus on the three conditions about which our understanding of the pathology \u2013 and in some cases the treatment options \u2013 has greatly increased: transient neonatal diabetes mellitus, permanent neonatal diabetes due to \u2018channelopathies\u2019 and immune dysregulation, polyendocrinopathy, enteropathy X-linked syndrome. &lt;i&gt;Conclusions:&lt;\/i&gt; Effective treatment of neonatal diabetes requires thorough understanding of the disease processes underlying this highly variable condition. As our knowledge of pancreatic development and physiology expands, so, too, do the treatment options for some patients.<\/jats:p>","DOI":"10.1159\/000110471","type":"journal-article","created":{"date-parts":[[2007,12,14]],"date-time":"2007-12-14T10:31:44Z","timestamp":1197628304000},"page":"32-36","source":"Crossref","is-referenced-by-count":2,"title":["Neonatal Diabetes"],"prefix":"10.1159","volume":"68","author":[{"given":"J.P.H.","family":"Shield","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"127","published-online":{"date-parts":[[2007,12,10]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.2337%2Fdb06-0094"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00125-002-0837-2"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.2337%2Fdc06-1813"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1038%2Fng0295-110"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1093%2Fhmg%2F9.4.589"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00439-001-0671-5"},{"key":"ref7","doi-asserted-by":"publisher","DOI":"10.1158%2F0008-5472.CAN-06-1529"},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1136%2Fjmg.39.12.872"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.2337%2Fdiabetes.49.8.1359"},{"key":"ref10","doi-asserted-by":"publisher","DOI":"10.1007%2FBF00441965"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00439-005-0127-4"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00439-006-0205-2"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1093%2Fhmg%2Fddi086"},{"key":"ref14","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa055068"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.2337%2Fdb06-1540"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.1080%2F07853890510007287"},{"key":"ref17","doi-asserted-by":"publisher","DOI":"10.1073%2Fpnas.0404756101"},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.2337%2Fdiabetes.53.10.2713"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1007%2Fs00125-005-1731-5"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJMoa061759"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1038%2F83707"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jaci.2006.10.007"},{"key":"ref23","doi-asserted-by":"publisher","DOI":"10.1097%2F00002281-200307000-00010"},{"key":"ref24","doi-asserted-by":"publisher","DOI":"10.1136%2Fjmg.39.8.537"},{"key":"ref25","doi-asserted-by":"publisher","DOI":"10.1097%2F00001574-200411000-00014"},{"key":"ref26","doi-asserted-by":"publisher","DOI":"10.1016%2Fj.jpeds.2005.04.017"},{"key":"ref27","doi-asserted-by":"publisher","DOI":"10.1056%2FNEJM200106073442304"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1182%2Fblood-2006-05-025072"}],"container-title":["Hormone Research in Paediatrics"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/110471","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/www.karger.com\/Article\/Pdf\/110471","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T02:05:40Z","timestamp":1745460340000},"score":1,"resource":{"primary":{"URL":"https:\/\/karger.com\/article\/doi\/10.1159\/000110471"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007]]},"references-count":28,"journal-issue":{"issue":"Suppl. 5","published-online":{"date-parts":[[2007,12,1]]}},"URL":"https:\/\/doi.org\/10.1159\/000110471","archive":["Portico"],"relation":{},"ISSN":["1663-2818","1663-2826"],"issn-type":[{"type":"print","value":"1663-2818"},{"type":"electronic","value":"1663-2826"}],"subject":[],"published":{"date-parts":[[2007]]}}}